Cytarabine

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Cat.No. 4520 - Cytarabine | C9H13N3O5 | CAS No. 147-94-4
Description: Nucleoside analog; inhibits DNA replication
Alternative Names: Cytosine b-D-arabinofuranoside
Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

M. Wt 243.22
Formula C9H13N3O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 147-94-4
PubChem ID 114682
InChI Key UHDGCWIWMRVCDJ-STUHELBRSA-N
Smiles O[C@@H]1[C@@H](CO)OC(N2C=CC(N)=NC2=O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.16 50
water 24.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 243.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.11 mL 20.56 mL 41.12 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
10 mM 0.41 mL 2.06 mL 4.11 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sampath et al (2006) Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517 PMID: 16293603

Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944 PMID: 10383159

Yang et al (1986) Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368 PMID: 2954403


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Citations for Cytarabine

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Cytarabine

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