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Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 243.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.11 mL||20.56 mL||41.12 mL|
|5 mM||0.82 mL||4.11 mL||8.22 mL|
|10 mM||0.41 mL||2.06 mL||4.11 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
References are publications that support the biological activity of the product.
Sampath et al (2006) Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517 PMID: 16293603
Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944 PMID: 10383159
Yang et al (1986) Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368 PMID: 2954403
If you know of a relevant reference for Cytarabine, please let us know.
Keywords: Cytarabine, Cytarabine supplier, Cytarabine, supplier, ara-C, araC, cytosine, beta-D-arabinofuranoside, arabinocytidine, DNA, replication, inhibits, nucleoside, analog, deoxycytidine, incorporates, synthesis, anticancer, antiproliferative, antineoplastic, antileukemic, leukemia, fragmentation, antimetabolite, Cytosine, b-D-arabinofuranoside, DNA,, RNA, and, Protein, Synthesis, 4520, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Cytarabine include:
Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882
Mathieson et al (2018) Systematic analysis of protein turnover in primary cells. Nat Commun 9 689 PMID: 29449567
Do you know of a great paper that uses Cytarabine from Tocris? Please let us know.
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Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.
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