Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 243.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.11 mL||20.56 mL||41.12 mL|
|5 mM||0.82 mL||4.11 mL||8.22 mL|
|10 mM||0.41 mL||2.06 mL||4.11 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Sampath et al (2006) Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517 PMID: 16293603
Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944 PMID: 10383159
Yang et al (1986) Effect of cytarabine upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368 PMID: 2954403
If you know of a relevant reference for Cytarabine, please let us know.
View Related Products by Product Action
Keywords: Cytarabine, supplier, Cytarabine, supplier, ara-C, araC, cytosine, beta-D-arabinofuranoside, arabinocytidine, DNA, replication, inhibits, nucleoside, analog, deoxycytidine, incorporates, synthesis, anticancer, antiproliferative, antineoplastic, antileukemic, leukemia, fragmentation, antimetabolite, Cytosine, b-D-arabinofuranoside, DNA,, RNA, and, Protein, Synthesis, DNA,, RNA, and, Protein, Synthesis, Tocris Bioscience
Citations for Cytarabine
Citations are publications that use Tocris products.
Currently there are no citations for Cytarabine. Do you know of a great paper that uses Cytarabine from Tocris? If so please let us know.