Cytarabine

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Cat.No. 4520 - Cytarabine | C9H13N3O5 | CAS No. 147-94-4
Description: Nucleoside analog; inhibits DNA replication
Alternative Names: Cytosine b-D-arabinofuranoside
Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity

Nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

M. Wt 243.22
Formula C9H13N3O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 147-94-4
PubChem ID 114682
InChI Key UHDGCWIWMRVCDJ-STUHELBRSA-N
Smiles O[C@@H]1[C@@H](CO)OC(N2C=CC(N)=NC2=O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.32 100
DMSO 12.16 50

Preparing Stock Solutions

The following data is based on the product molecular weight 243.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.11 mL 20.56 mL 41.12 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
10 mM 0.41 mL 2.06 mL 4.11 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Sampath et al (2006) Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 107 2517 PMID: 16293603

Breistøl et al (1999) Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models. Cancer Res. 59 2944 PMID: 10383159

Yang et al (1986) Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 7 368 PMID: 2954403


If you know of a relevant reference for Cytarabine, please let us know.

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⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

2 Citations for Cytarabine

Citations are publications that use Tocris products. Selected citations for Cytarabine include:

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882

Mathieson et al (2018) Systematic analysis of protein turnover in primary cells. Nat Commun 9 689 PMID: 29449567


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Reviews for Cytarabine

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An inhibitor of neurogenesis.
By Luiz Alexandre Magno on 07/16/2018
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: Brain

Cytarabine, also known as AraC, is an anti-mitotic drug. I have used it to inhibit neurogenesis. To deliver this drug into the brain, I implanted a chronic osmotic minipump with cannula located in the lateral ventricle of mice. The drug was diluted in NaCl 0.9% at 2% concentration (m/v) and delivered for 14 days. After treatment, a proliferative zone of the brain was immunolabeled for the doublecortin marker, which stains new neurons. The image shows that the mouse injected with Cytarabine (RIGHT) displayed no signal of new cells, suggesting that neurogenesis was blocked.

review image

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