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Biological Activity for Pritelivir
Pritelivir is a potent and selective herpes simplex virus (HSV) helicase primase inhibitor. Pritelivir inhibits viral replication in Vero cells (IC50 = 0.02 μM for HSV-1 and HSV-2). It also reduces β-amyloid and P-tau levels in Vero cells. Pritelivir is active against clinical isolates and porcine and bovine HSV strains but displays reduced activity against varicella zoster virus and cytomegalovirus in vitro. In addition, the compound exhibits antiviral activity in HSV infected mice.
Technical Data for Pritelivir
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pritelivir
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||20.12||50 with gentle warming|
Preparing Stock Solutions for Pritelivir
The following data is based on the product molecular weight 402.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.97 mL||24.85 mL||49.69 mL|
|2.5 mM||0.99 mL||4.97 mL||9.94 mL|
|5 mM||0.5 mL||2.48 mL||4.97 mL|
|25 mM||0.1 mL||0.5 mL||0.99 mL|
References for Pritelivir
References are publications that support the biological activity of the product.
Kleymann et al (2002) New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat.Med. 8 392 PMID: 11927946
Wozniak et al (2013) The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1. Antiviral Res. 99 401 PMID: 23867133
If you know of a relevant reference for Pritelivir, please let us know.
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Citations for Pritelivir
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