G418 disulfate salt

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Cat.No. 4131 - G418 disulfate salt | C20H40N4O10.2H2SO4 | CAS No. 108321-42-2
Description: Aminoglycoside antibiotic; used in cell culture
Datasheet
Citations
Literature

Biological Activity

Aminoglycosidic antibiotic. Inhibits protein synthesis in both prokaryotic and eukaryotic cells. Used for selection of eukaryotic cells transfected with the neo gene.

Technical Data

M. Wt 692.71
Formula C20H40N4O10.2H2SO4
Storage Store at +4°C
CAS Number 108321-42-2
PubChem ID 206347
InChI Key UHEPSJJJMTWUCP-DHDYTCSHSA-N
Smiles N[C@H]1[C@H](O[C@]2([H])[C@H](O)[C@@H](NC)[C@@](C)(O)CO2)[C@@H](O)[C@H](O[C@]3([H])[C@H](N)[C@@H](O)[C@H](O)[C@]([C@H](O)C)([H])O3)[C@@H](N)C1.OS(O)(=O)=O.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 51.95 75

Preparing Stock Solutions

The following data is based on the product molecular weight 692.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.22 mL 14.44 mL
5 mM 0.29 mL 1.44 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wagman et al (1974) Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation and preliminary characterization. Antimicrob.Agents Chemother. 6 144 PMID: 15828184

Bar-Nun et al (1983) G-418, an elongation inhibitor of 80 S ribosomes. Biochim.Biophys.Acta. 741 123 PMID: 6193810

Burke and Mogg (1985) Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Nucleic Acids Res. 13 6265 PMID: 2995924


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View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: antibiotics neomycin resistance cell culture aminoglycoside inhibitors inhibits protein synthesis eukaryotes eukaryotic prokaryotes prokaryotic DNA, RNA and Protein Synthesis

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