Pricing Availability   Qty
Description: Inhibitor of DHODH; active metabolite of Leflunomide
Alternative Names: A77 1726
Chemical Name: 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Purity: ≥99% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Teriflunomide

Teriflunomide is an inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Immunosuppressive agent. Active metabolite of leflunomide.

Compound Libraries for Teriflunomide

Teriflunomide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Teriflunomide

M. Wt 270.21
Formula C12H9F3N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 108605-62-5
PubChem ID 54684141
Smiles O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Teriflunomide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.02 100

Preparing Stock Solutions for Teriflunomide

The following data is based on the product molecular weight 270.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37.01 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for Teriflunomide

Certificate of Analysis / Product Datasheet
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References for Teriflunomide

References are publications that support the biological activity of the product.

Williamson et al (1995) Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J.Biol.Chem. 270 22467 PMID: 7673235

Davis et al (1996) The immunosuppressive metabolite of leflun. is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 35 1270 PMID: 8573583

Iglesias-Bregna et al (2013) Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 347 203 PMID: 23892570

If you know of a relevant reference for Teriflunomide, please let us know.

View Related Products by Product Action

View all Dihydroorotate Dehydrogenase Inhibitors

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2 Citations for Teriflunomide

Citations are publications that use Tocris products. Selected citations for Teriflunomide include:

Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779

Takashi et al (2022) Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models. Cell Rep 38 110268 PMID: 35045289

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Literature in this Area

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