Teriflunomide

Pricing Availability Delivery Time Qty
Cat.No. 5069 - Teriflunomide | C12H9F3N2O2 | CAS No. 108605-62-5
Description: Dihydroorotate dehydrogenase inhibitor
Alternative Names: A77 1726
Chemical Name: 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Imunosuppressive agent. Active metabolite of leflunomide (Cat. No. 2228).

Compound Libraries

Teriflunomide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 270.21
Formula C12H9F3N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 108605-62-5
PubChem ID 54684141
InChI Key UTNUDOFZCWSZMS-YFHOEESVSA-N
Smiles O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.02 100
ethanol 1.35 5mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 270.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37.01 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Williamson et al (1995) Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J.Biol.Chem. 270 22467 PMID: 7673235

Davis et al (1996) The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 35 1270 PMID: 8573583

Iglesias-Bregna et al (2013) Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 347 203 PMID: 23892570


If you know of a relevant reference for Teriflunomide, please let us know.

View Related Products by Product Action

View all Other Dehydrogenase Inhibitors

Keywords: Active metabolite leflunomide A771726 A 77-1726 A 771226 A77 1726 dihydroorolate dehydrogenase inhibitors inhibits immunosuppressive agent drug immunomodulatory A77 1726 Other Dehydrogenases

Citations for Teriflunomide

Citations are publications that use Tocris products.

Currently there are no citations for Teriflunomide. Do you know of a great paper that uses Teriflunomide from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Teriflunomide

Protocols

TODO: Add Protocols