YK 4-279

Pricing Availability Delivery Time Qty
Cat.No. 4067 - YK 4-279 | C17H13Cl2NO4 | CAS No. 1037184-44-3
Description: Inhibitor of RNA helicase A (RHA)
Chemical Name: 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.

Compound Libraries

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Technical Data

M. Wt 366.2
Formula C17H13Cl2NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1037184-44-3
PubChem ID 44632017
InChI Key HLXSCTYHLQHQDJ-UHFFFAOYSA-N
Smiles O=C2NC1=C(Cl)C=CC(Cl)=C1C(CC(C3=CC=C(OC)C=C3)=O)2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 366.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.31 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Erkizan et al (2009) Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma. Nat.Med. 15 750 PMID: 19584866


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Keywords: YK4-279 inhibits RNA helicase A inhibitors Ewing's sarcoma familty tumor ESFT EWS-FLI1 DNA, RNA and Protein Synthesis

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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  • Epigenetics in Cancer
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  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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