Trovafloxacin mesylate

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Cat.No. 3863 - Trovafloxacin mesylate | C20H15F3N4O3.CH3SO3H | CAS No. 147059-75-4
Description: Antibiotic; inhibits bacterial DNA synthesis
Alternative Names: CP 99219
Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Trovafloxacin mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 512.46
Formula C20H15F3N4O3.CH3SO3H
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 147059-75-4
PubChem ID 62960
InChI Key DYNZICQDCVYXFW-GIPYJWDTSA-N
Smiles O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.62 50
DMSO 51.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 512.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615 PMID: 7872757

Gootz et al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691 PMID: 9124824

Poon et al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329 PMID: 24646995


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Cancer

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