Trovafloxacin mesylate

Pricing Availability Delivery Time Qty
Cat.No. 3863 - Trovafloxacin mesylate | C20H15F3N4O3.CH3SO3H | CAS No. 147059-75-4
Description: Antibiotic; inhibits bacterial DNA synthesis
Alternative Names: CP 99219
Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate
Purity: ≥99% (HPLC)

Biological Activity

Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Trovafloxacin mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 512.46
Formula C20H15F3N4O3.CH3SO3H
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 147059-75-4
PubChem ID 62960
Smiles O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.25 100
water 25.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 512.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615 PMID: 7872757

Gootz et al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691 PMID: 9124824

Poon et al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329 PMID: 24646995

If you know of a relevant reference for Trovafloxacin mesylate, please let us know.

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Keywords: CP99219 antibiotics antibacterial antimicrobial DNA topoisomerase IV gyrase dna synthesis inhibitors inhibits Pfizer CP 99219 DNA, RNA and Protein Synthesis

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Cancer Research Product Guide

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