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High affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 495.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.09 mL||20.18 mL|
|5 mM||0.4 mL||2.02 mL||4.04 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References are publications that support the biological activity of the product.
Anderson et al (1979) Analysis of the anti-coccidial drug, halofunginone, in chicken feed using gas-liquid chromatography and high-performance liquid chromatography. J.Chromatogr. 168 471 PMID: 570196
Elkin et al (1999) Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clin.Cancer.Res. 5 1982 PMID: 10473075
Keller et al (2012) Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 8 311 PMID: 22327401
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Keywords: Halofuginone hydrobromide, Halofuginone hydrobromide supplier, High, affinity, competitive, prolyl-tRNA, synthetase, inhibitors, inhibits, metastasis, MMP2, matrix, metalloprotease, autoimmunity, antiparasitic, Other, Synthases/Synthetases, DNA,, RNA, and, Protein, Synthesis, 1993, Tocris Bioscience
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