Halofuginone hydrobromide

Pricing Availability   Qty
Description: High affinity competitive prolyl-tRNA synthetase inhibitor
Chemical Name: (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Purity: ≥98% (HPLC)

Biological Activity for Halofuginone hydrobromide

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Technical Data for Halofuginone hydrobromide

M. Wt 495.59
Formula C16H17BrClN3O3.HBr
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 64924-67-0
PubChem ID 400771
Smiles BrC1=CC2=C(C(N(CC(C[C@@H]3[C@H](O)CCCN3)=O)C=N2)=O)C=C1Cl.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Halofuginone hydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.56 100

Preparing Stock Solutions for Halofuginone hydrobromide

The following data is based on the product molecular weight 495.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Halofuginone hydrobromide

References for Halofuginone hydrobromide

References are publications that support the biological activity of the product.

Anderson et al (1979) Analysis of the anti-coccidial drug, halofunginone, in chicken feed using gas-liquid chromatography and high-performance liquid chromatography. J.Chromatogr. 168 471 PMID: 570196

Elkin et al (1999) Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clin.Cancer.Res. 5 1982 PMID: 10473075

Keller et al (2012) Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 8 311 PMID: 22327401

If you know of a relevant reference for Halofuginone hydrobromide, please let us know.

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: Halofuginone hydrobromide, Halofuginone hydrobromide supplier, High, affinity, competitive, prolyl-tRNA, synthetase, inhibitors, inhibits, metastasis, MMP2, matrix, metalloprotease, autoimmunity, antiparasitic, Other, Synthases/Synthetases, DNA,, RNA, and, Protein, Synthesis, 1993, Tocris Bioscience

Citations for Halofuginone hydrobromide

Citations are publications that use Tocris products.

Currently there are no citations for Halofuginone hydrobromide. Do you know of a great paper that uses Halofuginone hydrobromide from Tocris? Please let us know.

Reviews for Halofuginone hydrobromide

There are currently no reviews for this product. Be the first to review Halofuginone hydrobromide and earn rewards!

Have you used Halofuginone hydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review