Pricing Availability   Qty
Description: Inhibits eIF4E:eIF4G subunit interaction
Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
Purity: ≥98% (HPLC)
Citations (5)
Reviews (1)

Biological Activity for 4EGI-1

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data for 4EGI-1

M. Wt 451.28
Formula C18H12Cl2N4O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 315706-13-9
PubChem ID 6911989
Smiles OC(=O)C(\CC1=CC=CC=C1[N+]([O-])=O)=N/NC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4EGI-1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.13 100

Preparing Stock Solutions for 4EGI-1

The following data is based on the product molecular weight 451.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for 4EGI-1

References are publications that support the biological activity of the product.

Gkogkas et al (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 371 PMID: 23172145

Moerke et al (2007) Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128 257 PMID: 17254965

If you know of a relevant reference for 4EGI-1, please let us know.

Keywords: 4EGI-1, 4EGI-1 supplier, eIF4E, eIF4G, inhibitors, inhibits, interaction, cap-dependent, translation, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, 4800, Tocris Bioscience

5 Citations for 4EGI-1

Citations are publications that use Tocris products. Selected citations for 4EGI-1 include:

Christian et al (2022) High-throughput translational profiling with riboPLATE-seq. Sci Rep 12 5718 PMID: 35383235

Lei et al (2020) CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation. Neuron 105 475-490.e6 PMID: 31780330

Rolf et al (2018) The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling. Cell Metab 28 895-906.e5 PMID: 30197303

Michelle et al (2017) Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS One 12 e0177054 PMID: 28486555

Do you know of a great paper that uses 4EGI-1 from Tocris? Please let us know.

Reviews for 4EGI-1

Average Rating: 4 (Based on 1 Review.)

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(4EGI-1, 50 µM).
By Anonymous on 12/11/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: LP-1 cell line

Cells were treated with MG-132 (15 µM) for 18 hours in the absence or presence of an eIF4E/eIF4G interaction inhibitor (4EGI-1, 50 µM) or an MNK inhibitor (CGP57380, 10 μM).

PMID: 27626179
review image