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Cat.No. 4800 - 4EGI-1 | C18H12Cl2N4O4S | CAS No. 315706-13-9
Description: Inhibits eIF4E:eIF4G subunit interaction
Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data

M. Wt 451.28
Formula C18H12Cl2N4O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 315706-13-9
PubChem ID 6911989
Smiles OC(=O)C(\CC1=CC=CC=C1[N+]([O-])=O)=N/NC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 451.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References are publications that support the biological activity of the product.

Gkogkas et al (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 371 PMID: 23172145

Moerke et al (2007) Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128 257 PMID: 17254965

If you know of a relevant reference for 4EGI-1, please let us know.

Keywords: 4EGI-1, 4EGI-1 supplier, eIF4E, eIF4G, inhibitors, inhibits, interaction, cap-dependent, translation, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, 4800, Tocris Bioscience

1 Citation for 4EGI-1

Citations are publications that use Tocris products. Selected citations for 4EGI-1 include:

Riz et al (2016) Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget 7 66360 PMID: 27626179

Do you know of a great paper that uses 4EGI-1 from Tocris? Please let us know.

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