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Selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 331.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.02 mL||15.09 mL||30.18 mL|
|5 mM||0.6 mL||3.02 mL||6.04 mL|
|10 mM||0.3 mL||1.51 mL||3.02 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the biological activity of the product.
Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958 PMID: 11742973
Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003 PMID: 17603541
Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329 PMID: 18454043
If you know of a relevant reference for BIBR 1532, please let us know.
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Keywords: BIBR 1532, BIBR 1532 supplier, Selective, telomerase, inhibitors, inhibits, BIBR1532, Telomerase, DNA,, RNA, and, Protein, Synthesis, 2981, Tocris Bioscience
2 Citations for BIBR 1532
Citations are publications that use Tocris products. Selected citations for BIBR 1532 include:
Beyer et al (2016) Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res 118 856 PMID: 26699654
Farnung et al (2012) Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One 7 e35714 PMID: 22558207
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Reviews for BIBR 1532
Average Rating: 3 (Based on 1 Review.)
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Used BIBR 1532 as telomerase inhibitor at 2.5 uM with reproducible but moderate effects (expected).
Literature in this Area
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