BIBR 1532

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Description: Selective telomerase inhibitor
Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Purity: ≥98% (HPLC)
Citations (2)
Reviews (1)

Biological Activity for BIBR 1532

BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Compound Libraries for BIBR 1532

BIBR 1532 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BIBR 1532

M. Wt 331.36
Formula C21H17NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 321674-73-1
PubChem ID 9927531
Smiles C/C(C2=CC1=CC=CC=C1C=C2)=C\C(NC3=C(C(O)=O)C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BIBR 1532

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.14 100
ethanol 8.28 25

Preparing Stock Solutions for BIBR 1532

The following data is based on the product molecular weight 331.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for BIBR 1532

Certificate of Analysis / Product Datasheet
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References for BIBR 1532

References are publications that support the biological activity of the product.

Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958 PMID: 11742973

Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003 PMID: 17603541

Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329 PMID: 18454043

If you know of a relevant reference for BIBR 1532, please let us know.

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Keywords: BIBR 1532, BIBR 1532 supplier, Selective, telomerase, inhibitors, inhibits, BIBR1532, Telomerase, DNA,, RNA, and, Protein, Synthesis, 2981, Tocris Bioscience

2 Citations for BIBR 1532

Citations are publications that use Tocris products. Selected citations for BIBR 1532 include:

Beyer et al (2016) Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res 118 856 PMID: 26699654

Farnung et al (2012) Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One 7 e35714 PMID: 22558207

Do you know of a great paper that uses BIBR 1532 from Tocris? Please let us know.

Reviews for BIBR 1532

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Telomerase inhibitor in vitro.
By Maria Garcia Gonzalez on 07/12/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: H9C2

Used BIBR 1532 as telomerase inhibitor at 2.5 uM with reproducible but moderate effects (expected).