B02

Pricing Availability Delivery Time Qty
Cat.No. 6392 - B02 | C22H17N3O | CAS No. 1290541-46-6
Description: RAD51 recombinase inhibitor
Chemical Name: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

RAD51 recombinase inhibitor, exhibiting selectivity for human RAD51 over the E.coli homologue RecA (IC50 values are 27.4 μM and >250 μM, respectively). Inhibits homologous recombination and increases cellular sensitivity to DNA damage in vitro. Enhances the therapeutic effect of cisplatin (Cat. No. 2251) on tumor cells in vivo.

Technical Data

M. Wt 339.4
Formula C22H17N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1290541-46-6
PubChem ID 5738263
InChI Key GEKDQXSPTHHANP-OUKQBFOZSA-N
Smiles O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=CC=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 3.39 10
DMSO 33.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (2011) Identification of specific inhibitors of human RAD51 recombinase using high-throughputscreening. ACS Chem.Biol. 6 682 PMID: 21428443

Huang et al (2012) Inhibition of homologous recombination in human cells by targeting RAD51 recombinase. J.Med.Chem. 55 3011 PMID: 22380680

Alagpulinsa et al (2014) A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to doxorubicin. Front.Oncol. 4 289 PMID: 25401086

Huang and Mazin (2014) A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeuticagents in mouse xenografts. PLoS One 9 e100993 PMID: 24971740


If you know of a relevant reference for B02, please let us know.

View Related Products by Target

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: B02, supplier, B02, RAD51, recombinase, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, DNA,, RNA, and, Protein, Synthesis, Tocris Bioscience

Citations for B02

Citations are publications that use Tocris products.

Currently there are no citations for B02. Do you know of a great paper that uses B02 from Tocris? If so please let us know.

Reviews for B02

There are currently no reviews for this product. Be the first to review B02 and earn rewards!

Have you used B02?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis