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RAD51 recombinase inhibitor, exhibiting selectivity for human RAD51 over the E.coli homologue RecA (IC50 values are 27.4 μM and >250 μM, respectively). Inhibits homologous recombination and increases cellular sensitivity to DNA damage in vitro. Enhances the therapeutic effect of cisplatin (Cat. No. 2251) on tumor cells in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 339.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.95 mL||14.73 mL||29.46 mL|
|5 mM||0.59 mL||2.95 mL||5.89 mL|
|10 mM||0.29 mL||1.47 mL||2.95 mL|
|50 mM||0.06 mL||0.29 mL||0.59 mL|
References are publications that support the biological activity of the product.
Huang et al (2011) Identification of specific inhibitors of human RAD51 recombinase using high-throughputscreening. ACS Chem.Biol. 6 682 PMID: 21428443
Huang et al (2012) Inhibition of homologous recombination in human cells by targeting RAD51 recombinase. J.Med.Chem. 55 3011 PMID: 22380680
Alagpulinsa et al (2014) A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to dox. Front.Oncol. 4 289 PMID: 25401086
Huang and Mazin (2014) A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeuticagents in mouse xenografts. PLoS One 9 e100993 PMID: 24971740
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Keywords: B02, B02 supplier, B02, RAD51, recombinase, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, 6392, Tocris Bioscience
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