Dexrazoxane hydrochloride

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Cat.No. 3857 - Dexrazoxane hydrochloride | C11H16N4O4.HCl | CAS No. 1263283-43-7
Description: Topoisomerase II inhibitor
Alternative Names: ICRF-187
Chemical Name: 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Technical Data

M. Wt 304.73
Formula C11H16N4O4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1263283-43-7
PubChem ID 6918223
InChI Key BIFMNMPSIYHKDN-FJXQXJEOSA-N
Smiles C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.47 100
water 30.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 304.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.41 mL 32.82 mL
5 mM 0.66 mL 3.28 mL 6.56 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lebrecht et al (2007) Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br.J.Pharmacol 151 771 PMID: 17519947

Spallarossa et al (2010) Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. J.Pharmacol.Exp.Ther. 332 87 PMID: 19841470

Classen et al (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci. 100 10629 PMID:


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View Related Products by Product Action

View all DNA Topoisomerase Inhibitors

Keywords: topoisomerase II inhibitors inhibits DNA isomerases ICRF187 chemotherapeutics ICRF-187 DNA Topoisomerase

1 Citation for Dexrazoxane hydrochloride

Citations are publications that use Tocris products. Selected citations for Dexrazoxane hydrochloride include:

Gardner et al (2011) Geminin overexpression prevents the completion of topoisomerase II╬▒ chromosome decatenation, leading to aneuploidy in human mammary epithelial cells. Breast Cancer Res 13 R53 PMID: 21595939


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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Dexrazoxane hydrochloride

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