Emetine dihydrochloride

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Description: RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika
Chemical Name: (2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity for Emetine dihydrochloride

Emetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC50 = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC50 values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC50 = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.

Technical Data for Emetine dihydrochloride

M. Wt 553.57
Formula C29H40N2O4.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 316-42-7
PubChem ID 3068143
Smiles [H][C@@]1(NCCC2=CC(OC)=C(C=C12)OC)C[C@H]3C[C@@]4(N(C[C@@H]3CC)CCC5=CC(OC)=C(C=C45)OC)[H].Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Emetine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 55.36 100

Preparing Stock Solutions for Emetine dihydrochloride

The following data is based on the product molecular weight 553.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets for Emetine dihydrochloride

References for Emetine dihydrochloride

References are publications that support the biological activity of the product.

Yang et al (2018) Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 4 doi: 10.1038 PMID: 29872540

Choy (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 doi: 10.1016 PMID: 32251767

Bleasel et al (2020) Emetine, ipecac, ipecac alkaloids and analogues as potential antiviral agents for coronaviruses. Pharmaceuticals (Basel) 13 51 PMID: 32245264

Bleasel et al (2020) Emetine is not Ipecac: considerations for its use as treatment for SARS-CoV2. Pharmaceuticals (Basel) 13 428 PMID: 33261173

Killick et al (2020) Transcription-based drug repurposing for COVID-19. Virus Res. 290 198176 PMID: 32987033

If you know of a relevant reference for Emetine dihydrochloride, please let us know.

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Citations for Emetine dihydrochloride

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