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Biological Activity for Emetine dihydrochloride
Emetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC50 = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC50 values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC50 = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.
Technical Data for Emetine dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Emetine dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Emetine dihydrochloride
The following data is based on the product molecular weight 553.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.81 mL||9.03 mL||18.06 mL|
|5 mM||0.36 mL||1.81 mL||3.61 mL|
|10 mM||0.18 mL||0.9 mL||1.81 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
Product Datasheets for Emetine dihydrochloride
References for Emetine dihydrochloride
References are publications that support the biological activity of the product.
Yang et al (2018) Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 4 doi: 10.1038 PMID: 29872540
Choy (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 doi: 10.1016 PMID: 32251767
Bleasel et al (2020) Emetine, ipecac, ipecac alkaloids and analogues as potential antiviral agents for coronaviruses. Pharmaceuticals (Basel) 13 51 PMID: 32245264
Bleasel et al (2020) Emetine is not Ipecac: considerations for its use as treatment for SARS-CoV2. Pharmaceuticals (Basel) 13 428 PMID: 33261173
Killick et al (2020) Transcription-based drug repurposing for COVID-19. Virus Res. 290 198176 PMID: 32987033
If you know of a relevant reference for Emetine dihydrochloride, please let us know.
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Citations for Emetine dihydrochloride
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