Carboplatin

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Cat.No. 2626 - Carboplatin | C6H12N2O4Pt | CAS No. 41575-94-4
Description: DNA cross-linking antitumor agent
Alternative Names: NSC 241240, Paraplatin, JM 8
Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature
Pathways

Biological Activity

Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).

Technical Data

M. Wt 371.25
Formula C6H12N2O4Pt
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 41575-94-4
PubChem ID 10339178
InChI Key OLESAACUTLOWQZ-UHFFFAOYSA-L
Smiles O=C(C21CCC2)O[Pt-2]([NH3+])([NH3+])OC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.28 25

Preparing Stock Solutions

The following data is based on the product molecular weight 371.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.47 mL 26.94 mL
5 mM 0.54 mL 2.69 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Natarajan et al (1999) Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 58 1625 PMID: 10535754

Thomas et al (2006) High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol.Pharmacol. 70 23 PMID: 16569706

Yang et al (1995) Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res. 143 302 PMID:


If you know of a relevant reference for Carboplatin, please let us know.

Keywords: Carboplatin, supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducer, Synthesis, NSC241240, chemotherapeutics, NSC, 241240, Paraplatin, JM, 8, Apoptosis, Inducers, DNA,, RNA, and, Protein, Synthesis, Apoptosis, Inducers, Tocris Bioscience

2 Citations for Carboplatin

Citations are publications that use Tocris products. Selected citations for Carboplatin include:

Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Cell Death Differ 14 570 PMID: 25104095

Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306 PMID: 26218638


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Pathways for Carboplatin

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.