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The Tocriscreen™ PRO service allows you to design a completely custom compound library to meet your exact screening requirements. With this cherry-picking service, you can choose compounds from a list over 3,000 products from the Tocris catalog (minimum order ~80 wet or 30 dry compounds), as well as customize the format of the compounds (dry powder or in solution), and the tubes they are supplied in.
The bioactive compounds available through the Tocriscreen PRO service cover a wide range of targets, such as GPCRs, ion channels, enzymes, kinases, nuclear receptors and transporters, and all major research areas and product actions. Included are commonly used research standards, novel research tools, and pharmacologically active components of FDA-approved therapeutics.
As well as requesting a completely custom library, the Tocriscreen PRO service also allows you to select a pre-defined list of compounds. Currently available lists are:
The Tocris scientific team are ready to help you with choosing compounds and designing your bioactive compound library to fit your research needs. To help our team get started on your inquiry, please provide as much information as possible about your required compound format, research areas and targets, and if you require one of the pre-defined lists outlined above.
Please submit your requirements through the compound library inquiry form.
The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of biomedical research areas; neuroscience (36%), cancer (34%), endocrinology (9%), immunology (8%), cardiovascular (6%), stem cells (5%), other research areas (3%).
The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 24%), non-kinase enzymes (23%), kinases including enzyme-linked receptors (19%), ion channels (13%), cell biology targets (10%), nuclear receptors (5%), and transporters and other pharmacological targets (5%).
Danish et al (2021) A cellular assay for the identification and characterization of connexin gap junction modulators. Int.J.Mol.Sci. 22 1417 PMID: 33572565
Wazir et al (2021) Activity-based screening assay for mono-ADP-ribosylhydrolases. SLAS Discov. 26 67 PMID: 32527186
Yoon et al (2020) Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles. BMB Rep. 53 166 PMID: 31964466
Duvall et al (2019) Small-molecule agonists of Ae. aegypti neuropeptide Y receptor block mosquito biting. Cell. 176 687 PMID: 30735632
Fiedler et al (2019) MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo. Cell Stem Cell. 24 579 PMID: 30853557
Takeuchi et al (2019) Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor. PLoS One. 14 e0212233 PMID: 30779774
Mishra et al (2022) Improved loss-of-function CRISPR/Cas9 genome editing in human cells concomitant with inhibition of TGFβ signaling. Molecular Therapy: Nucleic Acid. 28 202 PMID: 35402072
Jang et al (2018) Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function. J.Virol 92 e01441 PMID: 30282713
Heins-Marroquin et al (2019) Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency. Brain.Commun. 1 fcz019 PMID: 32954262
McBrinn et al (2018) Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br.J.Pharmacol. 176 4521 PMID: 31368510
Cheng et al (2022) A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial type IVB secretion system. mBio. 13 e0024022 PMID: 35258332
Tsukamoto et al (2018) Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PLoS One. 13 e0197664 PMID: 29782545
Collia et al (2018) A rapid phenotypic whole-cell screening approach for the identification of small-molecule inhibitors that counter β-lactamase resistance in Pseudomonas aeruginosa. SLAS Discov. 23 55 PMID: 28850797
Zeng et al (2021) Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase. Biochem.J. 478 2405 PMID: 34198322
Canal et al (2021) Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease. Biochem.J. 478 2465 PMID: 34198324
Murer et al (2022) Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern. Curr.Res.Virol.Sci. 3 100019 PMID: 35072124
Mitsui et al (2019) Identification of ryuvidine as a KDM5A inhibitor. Sci.Rep. 9 9952 PMID: 31289306
Ghasemi et al (2018) High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines. Oncotarget 9 26064 PMID: 29899842
Mirabelli et al (2021) Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proc.Natl.Acad.Sci.U.S.A. 118 e2105815118 PMID: 34413211
Anerillas et al (2022) A BDNF-TrkB autocrine loop enhances senescent cell viability. Nat.Commun. 13 6228 PMID: 36266274
Harris et al (2019) Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion. Cell Metab. 29 1166 PMID: 30799286
Benítez et al (2022) Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening. J.Enzyme Inhib.Med.Chem. 37 912 PMID: 35306933