BMH 21

Pricing Availability Delivery Time Qty
Cat.No. 5417 - BMH 21 | C21H20N4O2 | CAS No. 896705-16-1
Description: RNA polymerase 1 inhibitor; also p53 pathway activator
Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Purity: ≥98% (HPLC)

Biological Activity

p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Technical Data

M. Wt 360.41
Formula C21H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 896705-16-1
PubChem ID 3508054
Smiles O=C2N4C(C(C(NCCN(C)C)=O)=CC=C4)=NC(C2=C3)=CC1=C3C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.8 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 360.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Peltonen et al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77 PMID: 24434211

Colis et al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950 PMID: 24847734

Peltonen et al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996 PMID: 20885994

If you know of a relevant reference for BMH 21, please let us know.

View Related Products by Product Action

View all RNA/DNA Polymerase Inhibitors

Keywords: BMH 21, supplier, BMH21, p53, pathway, activators, rna, polymerase, inhibitors, inhibits, RPA194, antitumor, RNA/DNA, Polymerase, DNA,, RNA, and, Protein, Synthesis, RNA, Polymerase, p53, RNA/DNA, Polymerase, Tocris Bioscience

Citations for BMH 21

Citations are publications that use Tocris products.

Currently there are no citations for BMH 21. Do you know of a great paper that uses BMH 21 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Pathways for BMH 21


TODO: Add Protocols