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p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.8||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||55.49 mL||277.46 mL||554.92 mL|
|0.25 mM||11.1 mL||55.49 mL||110.98 mL|
|0.5 mM||5.55 mL||27.75 mL||55.49 mL|
|2.5 mM||1.11 mL||5.55 mL||11.1 mL|
References are publications that support the biological activity of the product.
Peltonen et al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77 PMID: 24434211
Colis et al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950 PMID: 24847734
Peltonen et al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996 PMID: 20885994
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Keywords: BMH 21, BMH 21 supplier, BMH21, p53, pathway, activators, rna, polymerase, inhibitors, inhibits, RPA194, antitumor, RNA/DNA, Polymerase, DNA,, RNA, and, Protein, Synthesis, 5417, Tocris Bioscience
1 Citation for BMH 21
Citations are publications that use Tocris products. Selected citations for BMH 21 include:
McCullough et al (2018) Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry 8 164 PMID: 30135420
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.