BMH 21

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Cat.No. 5417 - BMH 21 | C21H20N4O2 | CAS No. 896705-16-1
Description: RNA polymerase 1 inhibitor; also p53 pathway activator
Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Technical Data

M. Wt 360.41
Formula C21H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 896705-16-1
PubChem ID 3508054
InChI Key BXYDVWIAGDJBEC-UHFFFAOYSA-N
Smiles O=C2N4C(C(C(NCCN(C)C)=O)=CC=C4)=NC(C2=C3)=CC1=C3C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.8 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 360.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 55.49 mL 277.46 mL 554.92 mL
0.25 mM 11.1 mL 55.49 mL 110.98 mL
0.5 mM 5.55 mL 27.75 mL 55.49 mL
2.5 mM 1.11 mL 5.55 mL 11.1 mL

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References

References are publications that support the biological activity of the product.

Peltonen et al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77 PMID: 24434211

Colis et al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950 PMID: 24847734

Peltonen et al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996 PMID: 20885994


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