eIF4A i28

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Description: eIF4A inhibitor
Chemical Name: 2-(5-(4-Butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for eIF4A i28

eIF4A i28 is a eukaryotic initiation factor-4A (eIF4A) inhibitor (IC50 = 8.60 μM in an eIF4A ATPase assay). It decreases BJAB Burkitt lymphoma cell viability (EC50 = 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. It acts as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.

Licensing Information

Sold under license from the University of Arizona

Technical Data for eIF4A i28

M. Wt 416.43
Formula C24H20N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2861994-92-3
PubChem ID 163198549
Smiles CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for eIF4A i28

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.33 20

Preparing Stock Solutions for eIF4A i28

The following data is based on the product molecular weight 416.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.01 mL 60.03 mL 120.07 mL
1 mM 2.4 mL 12.01 mL 24.01 mL
2 mM 1.2 mL 6 mL 12.01 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

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References for eIF4A i28

References are publications that support the biological activity of the product.

Zerio et al (2021) Discovery of an eIF4A inhibitor with a novel mechanism of action. J.Med.Chem. 64 15727 PMID: 34676755

If you know of a relevant reference for eIF4A i28, please let us know.

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Citations for eIF4A i28

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Literature in this Area

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