Brequinar sodium

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent and selective DHODH inhibitor
Alternative Names: BRQ,DuP 785,NSC 368390
Chemical Name: 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
Purity: ≥99% (HPLC)
Citations (3)
Literature (2)

Biological Activity for Brequinar sodium

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.

Compound Libraries for Brequinar sodium

Brequinar sodium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Brequinar sodium

M. Wt 397.35
Formula C23H14F2NO2Na
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 96201-88-6
PubChem ID 23663964
Smiles CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C4=C(C=CC=C4)F)C=C3)C(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Brequinar sodium

Solvent Max Conc. mg/mL Max Conc. mM
water 39.73 100
DMSO 39.73 100

Preparing Stock Solutions for Brequinar sodium

The following data is based on the product molecular weight 397.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Brequinar sodium

Certificate of Analysis / Product Datasheet
Select another batch:

References for Brequinar sodium

References are publications that support the biological activity of the product.

Arteaga (1989) Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390). Cancer Res. 49 4648 PMID: 2743343

Sykes et al (2016) Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell 167 171 PMID: 27641501

Peters et al (1987) Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390). Invest.New Drugs 5 235 PMID: 2822596

If you know of a relevant reference for Brequinar sodium, please let us know.

View Related Products by Product Action

View all Dihydroorotate Dehydrogenase Inhibitors

Keywords: Brequinar sodium, Brequinar sodium supplier, NSC368390, DuP785, BRQ, Biphenquinate, Brequinar, potent, selective, DHODH, inhibitors, inhibits, dihydroorotate, dehydrogenase, AML, acute, myeloid, leukemia, DuP, 785, NSC, 368390, Dihyroorotate, Dehydrogenase, DNA,, RNA, and, Protein, Synthesis, 6196, Tocris Bioscience

3 Citations for Brequinar sodium

Citations are publications that use Tocris products. Selected citations for Brequinar sodium include:

Juan et al (2022) Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells. Cell Death Discov 8 464 PMID: 36424385

Jessica A et al (2020) Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells. PLoS Genet 16 e1009117 PMID: 33201894

Sonia et al (2021) DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance. iScience 24 102494 PMID: 34113829

Do you know of a great paper that uses Brequinar sodium from Tocris? Please let us know.

Reviews for Brequinar sodium

There are currently no reviews for this product. Be the first to review Brequinar sodium and earn rewards!

Have you used Brequinar sodium?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Multiple Sclerosis Poster

Multiple Sclerosis Poster

Multiple sclerosis (MS) is an autoimmune disease that is characterized by focal demyelination and axon degeneration in the central nervous system. This poster summarizes the neurobiology and current therapies of MS.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.