Brequinar sodium

Pricing Availability Delivery Time Qty
Cat.No. 6196 - Brequinar sodium | C23H14F2NO2Na | CAS No. 96201-88-6
Description: Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor
Alternative Names: BRQ, DuP 785, NSC 368390
Chemical Name: 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
Purity: ≥99% (HPLC)

Biological Activity

Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.

Technical Data

M. Wt 397.35
Formula C23H14F2NO2Na
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 96201-88-6
PubChem ID 23663964
Smiles CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C4=C(C=CC=C4)F)C=C3)C(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.73 100
water 39.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 397.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Arteaga (1989) Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390). Cancer Res. 49 4648 PMID: 2743343

Sykes et al (2016) Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell 167 171 PMID: 27641501

Peters et al (1987) Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390). Invest.New Drugs 5 235 PMID: 2822596

If you know of a relevant reference for Brequinar sodium, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Dehydrogenase Inhibitors

Keywords: Brequinar sodium, supplier, NSC368390, DuP785, BRQ, Biphenquinate, Brequinar, potent, selective, DHODH, inhibitors, inhibits, dihydroorotate, dehydrogenase, AML, acute, myeloid, leukemia, BRQ, DuP, 785, NSC, 368390, Other, Dehydrogenases, Other, Dehydrogenases, Tocris Bioscience

Citations for Brequinar sodium

Citations are publications that use Tocris products.

Currently there are no citations for Brequinar sodium. Do you know of a great paper that uses Brequinar sodium from Tocris? If so please let us know.

Brequinar sodium Reviews

Average Rating:

(Based on 0 Reviews)

1 Star
2 Star
3 Star
4 Star
5 Star

Have you used Brequinar sodium?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells