Protein-synthesizing GTPases

Translational GTPases (EC 3.6.5.3) facilitate and control the process of protein synthesis from RNA, through translation. This protein family contains initiation factors and elongation factors, which are found in both prokaryotes and eukaryotes.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3657 Sal 003
Inhibitor of eIF2α dephosphorylation; cell permeable
2347 Salubrinal
Selective inhibitor of eIF2α dephosphorylation

Other

Cat No Product Name / Activity
4215 4E1RCat
Inhibits eIF4F subunit interaction; inhibits protein translation
4800 4EGI-1
Inhibits eIF4E:eIF4G subunit interaction
4501 Ribavirin
Blocks eIF4E activity; antiviral guanosine analog

Translational GTPases (EC 3.6.5.3) facilitate and control the process of protein synthesis from RNA, through translation. This protein family contains initiation factors and elongation factors, which are found in both prokaryotes and eukaryotes.

Initiation factors (IFs) are involved in the first phase of translation; in prokaryotes these are named PIF1-3, while in eukaryotes there are at least 12 IFs and each is composed of multiple polypeptides. Eukaryotic IFs (eIFs) each have a slightly different role within translation, including start codon recognition, assembly of required complexes and association of the small and large ribosomal subunits. eIFs all bind to the small 40S ribosomal subunit, except for eIF6, which binds to the large 60S ribosomal subunit. Modulation and control of eIF function occurs through their interaction with signaling proteins, particularly those of the PI 3-kinase and MAPK pathways.

Elongation factors (EFs) in prokaryotes and eukaryotes are very similar. In prokaryotes three EFs exist (EF-Tu, EF-Ts and EF-G), while in eukaryotes there are two EFs that control elongation, eEF-1 and eEF-2. eEF-1 is composed of two subunits; the α-subunit mediates entry of transfer RNA to the free site of a ribosome, while the β-subunit acts as a guanine nucleotide exchange factor and catalyzes the release of GDP from the ?-subunit. At the end of each round of protein elongation, eEF-2 catalyzes the translocation of tRNA and mRNA down the ribosome.

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    Literature for Protein-synthesizing GTPases

    Tocris offers the following scientific literature for Protein-synthesizing GTPases to showcase our products. We invite you to request* or download your copy today!

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    Protein Synthesizing GTPases Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    eIF4A1 Human EIF4A1 NM_001416 P60842
    Mouse Eif4a1 NM_144958 P60843
    Rat Eif4a1 NM_199372 NP_955404
    eIF4A2 Human EIF4A2 NM_001967 Q14240
    Mouse Eif4a2 NM_013506 P10630
    Rat Eif4a2 NM_001008335 NP_001008336
    eIF4A3 Human EIF4A3 NM_014740 P38919
    Mouse Eif4a3 NM_138669 NP_619610
    Rat Eif4a3 NM_001100158 NP_001093628
    eIF4E Human EIF4E NM_001968 P06730
    Mouse Eif4e NM_007917 P63073
    Rat Eif4e NM_053974 NP_446426
    eIF4E2 Human EIF4E2 NM_004846 O60573
    Mouse Eif4e2 NM_001039170 Q8BMB3
    Rat Eif4e2 NM_001108808 NP_001102278
    eIF4E3 Human EIF4E3 NM_173359 Q8N5X7
    Mouse Eif4e3 NM_025829 Q9DBB5
    Rat Eif4e3 NM_001106612 NP_001100082
    eIF4G1 Human EIF4G1 NM_182917 Q04637
    Mouse Eif4g1 NM_145941 Q6NZJ6
    Rat Eif4g1 XM_006221194 XP_006221256
    eIF4G3 Human EIF4G3 NM_003760 O43432
    Mouse Eif4g3 NM_172703 Q80XI3
    Rat Eif4g3 NM_001106693 NP_001100163