Anticancer agent that is clinically used to treat nonlymphocytic leukemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 50 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 563.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.87 mL||17.73 mL|
|5 mM||0.35 mL||1.77 mL||3.55 mL|
|10 mM||0.18 mL||0.89 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Aubel-Sadron and Londos-Gagliardi (1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66 333 PMID: 6380596
Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727 PMID: 10075079
Laurent and Jaffrezou (2001) Signaling pathways activated by daunorubicin. Blood 98 913 PMID: 11493433
Dickey et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 1 6 PMID: 16930453
If you know of a relevant reference for Daunorubicin hydrochloride, please let us know.
View Related Products by Product Action
Keywords: RNA synthesis inhibitors inhibits antibiotics chemotherapeutics Daunomycin DNA, RNA and Protein Synthesis
1 Citation for Daunorubicin hydrochloride
Citations are publications that use Tocris products. Selected citations for Daunorubicin hydrochloride include:
Jones et al (2013) An alternative direct compound dispensing method using the HP D300 digital dispenser. PLoS One 18 367 PMID: 23708834
Do you know of a great paper that uses Daunorubicin hydrochloride from Tocris? If so please let us know.