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Biological Activity for Daptomycin
Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.
Technical Data for Daptomycin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Daptomycin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Daptomycin
The following data is based on the product molecular weight 1620.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.62 mL||3.09 mL||6.17 mL|
|5 mM||0.12 mL||0.62 mL||1.23 mL|
|10 mM||0.06 mL||0.31 mL||0.62 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References for Daptomycin
References are publications that support the biological activity of the product.
Tally and DeBruin (2000) Development of dapto. for gram-positive infections. J.Antimicrob Chemother. 46 523 PMID: 11020247
Jung et al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic dapto. Chem.Biol. 11 949 PMID: 15271353
Steenbergen et al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283 PMID: 15705644
Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501 PMID: 20522545
If you know of a relevant reference for Daptomycin, please let us know.
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1 Citation for Daptomycin
Citations are publications that use Tocris products. Selected citations for Daptomycin include:
Jane C et al (2021) Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane. Elife 10 PMID: 33821795
Do you know of a great paper that uses Daptomycin from Tocris? Please let us know.
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Literature in this Area
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