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Description: Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria
Alternative Names: LY 146032
Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone
Purity: ≥95% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Daptomycin

Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Technical Data for Daptomycin

M. Wt 1620.67
Formula C72H101N17O26
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 103060-53-3
PubChem ID 16129629
Smiles O=C(N[C@@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C4=O)=O)=O)CN[C@]([C@H]([C@H](OC([C@@H](NC([C@@H](NC([C@@H](CO)NC(CNC([C@@H](N4)CC(O)=O)=O)=O)=O)[C@@H](C)CC(O)=O)=O)CC(C3=CC=CC=C3N)=O)=O)C)NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CCCCCCCCC)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Daptomycin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 162.07 100
water 32.41 20

Preparing Stock Solutions for Daptomycin

The following data is based on the product molecular weight 1620.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.09 mL 6.17 mL
5 mM 0.12 mL 0.62 mL 1.23 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets for Daptomycin

Certificate of Analysis / Product Datasheet
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References for Daptomycin

References are publications that support the biological activity of the product.

Tally and DeBruin (2000) Development of dapto. for gram-positive infections. J.Antimicrob Chemother. 46 523 PMID: 11020247

Jung et al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic dapto. Chem.Biol. 11 949 PMID: 15271353

Steenbergen et al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283 PMID: 15705644

Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501 PMID: 20522545

If you know of a relevant reference for Daptomycin, please let us know.

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Keywords: Daptomycin, Daptomycin supplier, antibiotics, lipopeptide, Gram-positive, bacteria, infection, bacteriocidal, inhibitors, inhibits, protein, DNA, synthesis, LY146032, LY, 146032, antibacterial, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 3917, Tocris Bioscience

1 Citation for Daptomycin

Citations are publications that use Tocris products. Selected citations for Daptomycin include:

Jane C et al (2021) Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane. Elife 10 PMID: 33821795

Do you know of a great paper that uses Daptomycin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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