Lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1620.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.62 mL||3.09 mL||6.17 mL|
|5 mM||0.12 mL||0.62 mL||1.23 mL|
|10 mM||0.06 mL||0.31 mL||0.62 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tally and DeBruin (2000) Development of daptomycin for gram-positive infections. J.Antimicrob Chemother. 46 523 PMID: 11020247
Jung et al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem.Biol. 11 949 PMID: 15271353
Steenbergen et al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283 PMID: 15705644
Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501 PMID: 20522545
If you know of a relevant reference for Daptomycin, please let us know.
View Related Products by Product Action
Keywords: Daptomycin, supplier, antibiotics, lipopeptide, Gram-positive, bacteria, infection, bacteriocidal, inhibitors, inhibits, protein, DNA, synthesis, LY146032, LY, 146032, antibacterial, LY, 146032, DNA,, RNA, and, Protein, Synthesis, Tocris Bioscience
Citations for Daptomycin
Citations are publications that use Tocris products.
Currently there are no citations for Daptomycin. Do you know of a great paper that uses Daptomycin from Tocris? If so please let us know.