You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LNT 1 New
Potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 332.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.02 mL||30.09 mL||60.18 mL|
|2.5 mM||1.2 mL||6.02 mL||12.04 mL|
|5 mM||0.6 mL||3.01 mL||6.02 mL|
|25 mM||0.12 mL||0.6 mL||1.2 mL|
References are publications that support the biological activity of the product.
Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID: 27526030
Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID: 28628639
If you know of a relevant reference for LNT 1, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LNT 1, LNT 1 supplier, LNT1, structure-specific, nuclease, human, flap, endonuclease-1, hFEN1, potent, inhibitors, inhibits, DNA, damage, response, Other, Hydrolases, DNA,, RNA, and, Protein, Synthesis, 6510, Tocris Bioscience
Citations for LNT 1
Citations are publications that use Tocris products.
Currently there are no citations for LNT 1. Do you know of a great paper that uses LNT 1 from Tocris? Please let us know.
Reviews for LNT 1
There are currently no reviews for this product. Be the first to review LNT 1 and earn rewards!
Have you used LNT 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)New
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells