LNT 1

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Cat.No. 6510 - LNT 1 | C15H12N2O5S | CAS No. 824983-91-7
Description: Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
Chemical Name: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.

Technical Data

M. Wt 332.33
Formula C15H12N2O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 824983-91-7
PubChem ID 11652865
InChI Key MXQGCMQXTPTJJT-UHFFFAOYSA-N
Smiles ON1C(N(C2=C(C1=O)SC=C2)CC3COC4=CC=CC=C4O3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 332.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.02 mL 30.09 mL 60.18 mL
2.5 mM 1.2 mL 6.02 mL 12.04 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

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References

References are publications that support the biological activity of the product.

Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID: 27526030

Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID: 28628639


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Citations for LNT 1

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