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Inhibitor of RNA polymerase II. Inhibits transcription in eukaryotic cells. Binds and blocks the largest subunits of RNA polymerase II, preventing new ribonucleotides from incorporating into the nascent RNA chain. Potent amatoxin.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 918.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||21.76 mL||108.82 mL||217.63 mL|
|0.25 mM||4.35 mL||21.76 mL||43.53 mL|
|0.5 mM||2.18 mL||10.88 mL||21.76 mL|
|2.5 mM||0.44 mL||2.18 mL||4.35 mL|
References are publications that support the biological activity of the product.
Casse et al (1999) The transcriptional inhibitors, actinomycin D and α-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain. J.Biol.Chem. 274 16097 PMID: 10347161
Raha et al (2010) Close association of RNA polymerase II and many transcription factors with Pol III genes. Proc.Natl.Acad.Sci. 107 3639
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Citations for α-Amanitin
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Reviews for α-Amanitin
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alpha -Amanitin was used in antibacterial resistance experiments.We looked into RNAP translocation along the DNA without dissociating from either the template or the growing RNA product until it encounters a termination factor or signal that causes the transcription cycle end with dissociation of the transcribing complex and release of RNA polymerase for a new round of transcription.
Literature in this Area
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.