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Biological Activity for Lin28 1632
Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity. Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.
Compound Libraries for Lin28 1632
Technical Data for Lin28 1632
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Lin28 1632
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Lin28 1632
The following data is based on the product molecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.55 mL||17.77 mL||35.55 mL|
|5 mM||0.71 mL||3.55 mL||7.11 mL|
|10 mM||0.36 mL||1.78 mL||3.55 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
References for Lin28 1632
References are publications that support the biological activity of the product.
Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773 PMID: 27548809
Chen et al (2019) LIN28/ let-7/PD-L1 pathway as a target for cancer immunotherapy. Cancer Immunol.Res. 7 487 PMID: 30651289
Chen et al (2019) Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis. Oncogene 38 4527 PMID: 30742065
If you know of a relevant reference for Lin28 1632, please let us know.
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Keywords: Lin28 1632, Lin28 1632 supplier, Lin281632, RNA-binding, protein, Lin28, stem, cell, differentiation, bromodomains, inhibitors, inhibits, PD-L1, let-7, antitumor, immunity, Bromodomains, DNA,, RNA, and, Protein, Synthesis, ESCs, iPSC, Immune, Checkpoints, 6068, Tocris Bioscience
3 Citations for Lin28 1632
Citations are publications that use Tocris products. Selected citations for Lin28 1632 include:
Alfredo et al (2020) Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming. Front Cell Dev Biol 8 562940 PMID: 33330447
Miguel N et al (2020) LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability. Cell Rep 30 4567-4583.e5 PMID: 32234488
Yoji et al (2021) Lin28A/let-7 oncogenic circuit is a potential therapeutic target in neurocutaneous melanosis-associated CNS tumors in children. Neurooncol Adv 3 vdaa174 PMID: 33506207
Do you know of a great paper that uses Lin28 1632 from Tocris? Please let us know.
Reviews for Lin28 1632
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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