Lin28 1632

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Cat.No. 6068 - Lin28 1632 | C15H15N5O | CAS No. 108825-65-6
Description: RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
Chemical Name: N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Also bromodomain inhibitor.

Technical Data

M. Wt 281.31
Formula C15H15N5O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 108825-65-6
PubChem ID 2737312
InChI Key WPAQLESUVYGUJZ-UHFFFAOYSA-N
Smiles CN(C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.13 100
ethanol 28.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773 PMID: 27548809


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Keywords: Lin281632 RNA-binding protein Lin28 stem cell differentiation bromodomains inhibitors inhibits DNA, RNA and Protein Synthesis

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Cancer

Cancer Research Product Guide

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