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Biological Activity for Lin28 1632
Lin28 1632 is a RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity. Also bromodomain inhibitor.
Compound Libraries for Lin28 1632
Technical Data for Lin28 1632
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Lin28 1632
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Lin28 1632
The following data is based on the product molecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.55 mL||17.77 mL||35.55 mL|
|5 mM||0.71 mL||3.55 mL||7.11 mL|
|10 mM||0.36 mL||1.78 mL||3.55 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
References for Lin28 1632
References are publications that support the biological activity of the product.
Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773 PMID: 27548809
Chen et al (2019) LIN28/ let-7/PD-L1 pathway as a target for cancer immunotherapy. Cancer Immunol.Res. 7 487 PMID: 30651289
If you know of a relevant reference for Lin28 1632, please let us know.
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Keywords: Lin28 1632, Lin28 1632 supplier, Lin281632, RNA-binding, protein, Lin28, stem, cell, differentiation, bromodomains, inhibitors, inhibits, PD-L1, let-7, antitumor, immunity, Bromodomains, DNA,, RNA, and, Protein, Synthesis, ESCs, iPSC, Immune, Checkpoints, 6068, Tocris Bioscience
Citations for Lin28 1632
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Reviews for Lin28 1632
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
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