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Description: Survivin suppressor
Alternative Names: sepantronium bromide
Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Purity: ≥98% (HPLC)
Biological Activity for YM 155
YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.
Compound Libraries for YM 155
YM 155 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for YM 155
| M. Wt | 443.29 |
| Formula | C20H19BrN4O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 781661-94-7 |
| PubChem ID | 46931000 |
| InChI Key | OOLCTHGNPMKPRV-UHFFFAOYSA-M |
| Smiles | COCCN1C(C)=[N+](C2=C1C(C3=CC=CC=C3C2=O)=O)CC4=NC=CN=C4.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for YM 155
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.33 | 100 | |
| DMSO | 8.87 | 20 |
Preparing Stock Solutions for YM 155
The following data is based on the product molecular weight 443.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.28 mL | 22.56 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets for YM 155
References for YM 155
References are publications that support the biological activity of the product.
Iwasa et al (2008) Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin.Cancer Res. 14 6496 PMID: 18927289
Premkumar et al (2013) Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J.Pharmacol.Exp.Ther. 346 201 PMID: 23740602
Serafini et al (2023) SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 16 eade4984 PMID: 37159520
If you know of a relevant reference for YM 155, please let us know.
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2 Citations for YM 155
Citations are publications that use Tocris products. Selected citations for YM 155 include:
Eric et al (2019) Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Dev Cell 49 393-408.e7 PMID: 30982660
Serafini et al (2023) SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 16 eade4984 PMID: 37159520
Do you know of a great paper that uses YM 155 from Tocris? Please let us know.
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Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for YM 155
