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YM 155

Cat. No. 6491 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Survivin suppressor
Alternative Names: sepantronium bromide
Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for YM 155

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

Compound Libraries for YM 155

YM 155 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YM 155

M. Wt 443.29
Formula C20H19BrN4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 781661-94-7
PubChem ID 46931000
InChI Key OOLCTHGNPMKPRV-UHFFFAOYSA-M
Smiles COCCN1C(C)=[N+](C2=C1C(C3=CC=CC=C3C2=O)=O)CC4=NC=CN=C4.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for YM 155

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.33 100
DMSO 8.87 20

Preparing Stock Solutions for YM 155

The following data is based on the product molecular weight 443.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for YM 155

References are publications that support the biological activity of the product.

Iwasa et al (2008) Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin.Cancer Res. 14 6496 PMID: 18927289

Premkumar et al (2013) Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J.Pharmacol.Exp.Ther. 346 201 PMID: 23740602

Serafini et al (2023) SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 16 eade4984 PMID: 37159520

If you know of a relevant reference for YM 155, please let us know.

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2 Citations for YM 155

Citations are publications that use Tocris products. Selected citations for YM 155 include:

Serafini et al (2023) SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 16 eade4984 PMID: 37159520

Eric et al (2019) Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Dev Cell 49 393-408.e7 PMID: 30982660

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Literature in this Area

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for YM 155

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.