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Description: Antibiotic; inhibits protein synthesis in gram-positive bacteria
Alternative Names: PNU 100766,U 100766
Chemical Name: N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
Purity: ≥99% (HPLC)
Reviews (2)
Literature (2)

Biological Activity for Linezolid

Linezolid is an oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Linezolid

Linezolid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Linezolid

M. Wt 337.35
Formula C16H20FN3O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 165800-03-3
PubChem ID 441401
Smiles FC1=CC(N3C[C@H](CNC(C)=O)OC3=O)=CC=C1N2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Linezolid

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.74 100
ethanol 8.43 25

Preparing Stock Solutions for Linezolid

The following data is based on the product molecular weight 337.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

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Citations for Linezolid

Citations are publications that use Tocris products.

Currently there are no citations for Linezolid. Do you know of a great paper that uses Linezolid from Tocris? Please let us know.

Reviews for Linezolid

Average Rating: 4.5 (Based on 2 Reviews.)

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Used Linezolid to identify its effectivenes against MRSA infections.
By Anonymous on 02/18/2019
Species: Human

Used Linezolid to identify its effectivenes against MRSA infections caused by hospitalization.

review image

Linezolid was used in resistance studies.
By Jade Smith on 02/05/2019
Species: Human

Linezolid was used in resistance studies. Antibiotic susceptibility testing was done for each isolate by the Kirby-Bauer disc diffusion method (DDM). The antibiotic works ideally and would use again.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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