Pricing Availability Delivery Time Qty
Cat.No. 3765 - Linezolid | C16H20FN3O4 | CAS No. 165800-03-3
Description: Antibiotic; inhibits protein synthesis in gram-positive bacteria
Alternative Names: PNU 100766, U 100766
Chemical Name: N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
Purity: ≥99% (HPLC)

Biological Activity

Oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Linezolid is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 337.35
Formula C16H20FN3O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 165800-03-3
PubChem ID 441401
Smiles FC1=CC(N3C[C@H](CNC(C)=O)OC3=O)=CC=C1N2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.74 100
ethanol 8.43 25

Preparing Stock Solutions

The following data is based on the product molecular weight 337.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Brickner et al (1996) Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections. J.Med.Chem. 39 673 PMID: 8576909

Ford et al (1996) In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob.Agents Chemother. 40 1508 PMID: 8726028

Brickner et al (2008) Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J.Med.Chem. 51 1981 PMID: 18338841

If you know of a relevant reference for Linezolid, please let us know.

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: PNU100766 U100766 antibacterial antibiotics gram-positive bacteria protein synthesis inhibitors inhibits Pfizer PNU 100766 U 100766 DNA, RNA and Protein Synthesis

Citations for Linezolid

Citations are publications that use Tocris products.

Currently there are no citations for Linezolid. Do you know of a great paper that uses Linezolid from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Linezolid


TODO: Add Protocols