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Cat.No. 3765 - Linezolid | C16H20FN3O4 | CAS No. 165800-03-3
Description: Antibiotic; inhibits protein synthesis in gram-positive bacteria
Alternative Names: PNU 100766, U 100766
Chemical Name: N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
Purity: ≥99% (HPLC)
Reviews (2)
Literature (1)

Biological Activity

Oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Linezolid is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 337.35
Formula C16H20FN3O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 165800-03-3
PubChem ID 441401
Smiles FC1=CC(N3C[C@H](CNC(C)=O)OC3=O)=CC=C1N2CCOCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.74 100
ethanol 8.43 25

Preparing Stock Solutions

The following data is based on the product molecular weight 337.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References are publications that support the biological activity of the product.

Brickner et al (1996) Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections. J.Med.Chem. 39 673 PMID: 8576909

Ford et al (1996) In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob.Agents Chemother. 40 1508 PMID: 8726028

Brickner et al (2008) Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J.Med.Chem. 51 1981 PMID: 18338841

If you know of a relevant reference for Linezolid, please let us know.

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View all DNA, RNA and Protein Synthesis Inhibitors

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Citations for Linezolid

Citations are publications that use Tocris products.

Currently there are no citations for Linezolid. Do you know of a great paper that uses Linezolid from Tocris? Please let us know.

Reviews for Linezolid

Average Rating: 4.5 (Based on 2 Reviews.)

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Used Linezolid to identify its effectivenes against MRSA infections.
By Anonymous on 02/18/2019
Species: Human

Used Linezolid to identify its effectivenes against MRSA infections caused by hospitalization.

review image

Linezolid was used in resistance studies.
By Jade Smith on 02/05/2019
Species: Human

Linezolid was used in resistance studies. Antibiotic susceptibility testing was done for each isolate by the Kirby-Bauer disc diffusion method (DDM). The antibiotic works ideally and would use again.

review image

Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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