Viomycin

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Cat.No. 3787 - Viomycin | C25H43N13O10.2H2SO4
Description: Antibiotic; inhibits bacterial DNA synthesis
Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Datasheet
Citations (4)
Reviews (1)
Literature (1)

Biological Activity for Viomycin

Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Viomycin

M. Wt 881.85
Formula C25H43N13O10.2H2SO4
Storage Store at -20°C
PubChem ID 90488875
InChI Key HMKHTQGEDRQEOM-IGZVKJTASA-N
Smiles O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Viomycin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 66.14 75

Preparing Stock Solutions for Viomycin

The following data is based on the product molecular weight 881.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 1.51 mL 7.56 mL 15.12 mL
3.75 mM 0.3 mL 1.51 mL 3.02 mL
7.5 mM 0.15 mL 0.76 mL 1.51 mL
37.5 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for Viomycin

References are publications that support the biological activity of the product.

Ermolenko et al (2007) The antibiotic vio. traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838


If you know of a relevant reference for Viomycin, please let us know.

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: Viomycin, Viomycin supplier, Viomycin, disulfate, Pfizer, antibiotics, inhibits, inhibitors, bacterial, DNA, synthesis, 37883-00-4, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 3787, Tocris Bioscience

4 Citations for Viomycin

Citations are publications that use Tocris products. Selected citations for Viomycin include:

Abad et al (2018) Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer. Mol Cell Proteomics PMID: 30373788

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478

Akbergenov et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreo. and vio. Antimicrob Agents Chemother 55 4712 PMID: 21768509

Freihofer et al (2016) Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. RNA 22 1836 PMID: 27698071


Do you know of a great paper that uses Viomycin from Tocris? Please let us know.

Reviews for Viomycin

Average Rating: 4 (Based on 1 Review.)

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Viomycin and streptomycin were compared in inhibition of bacterial protein production.
By Anonymous on 02/13/2019
Species: Human

Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.

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Literature in this Area

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