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Cat.No. 3787 - Viomycin | C25H43N13O10.2H2SO4 | CAS No. 32988-50-4
Description: Antibiotic; inhibits bacterial DNA synthesis
Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Citations (2)
Reviews (1)

Biological Activity

Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 881.85
Formula C25H43N13O10.2H2SO4
Storage Store at -20°C
CAS Number 32988-50-4
PubChem ID 90488875
Smiles O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 66.14 75

Preparing Stock Solutions

The following data is based on the product molecular weight 881.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 1.51 mL 7.56 mL 15.12 mL
3.75 mM 0.3 mL 1.51 mL 3.02 mL
7.5 mM 0.15 mL 0.76 mL 1.51 mL
37.5 mM 0.03 mL 0.15 mL 0.3 mL

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References are publications that support the biological activity of the product.

Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838

If you know of a relevant reference for Viomycin, please let us know.

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View all DNA, RNA and Protein Synthesis Inhibitors

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2 Citations for Viomycin

Citations are publications that use Tocris products. Selected citations for Viomycin include:

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478

Akbergenov et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Agents Chemother 55 4712 PMID: 21768509

Do you know of a great paper that uses Viomycin from Tocris? Please let us know.

Reviews for Viomycin

Average Rating: 4 (Based on 1 Review.)

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Viomycin and streptomycin were compared in inhibition of bacterial protein production: Good publishable, would use again.
By Anonymous on 02/13/2019
Species: Human

Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.

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