Viomycin

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Cat.No. 3787 - Viomycin | C25H43N13O10.2H2SO4 | CAS No. 32988-50-4
Description: Antibiotic; inhibits bacterial DNA synthesis
Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Datasheet
Citations (1)
Literature

Biological Activity

Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 881.85
Formula C25H43N13O10.2H2SO4
Storage Store at -20°C
CAS Number 32988-50-4
PubChem ID 90488875
InChI Key HMKHTQGEDRQEOM-IGZVKJTASA-N
Smiles O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 66.14 75

Preparing Stock Solutions

The following data is based on the product molecular weight 881.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.13 mL 5.67 mL 11.34 mL
5 mM 0.23 mL 1.13 mL 2.27 mL
10 mM 0.11 mL 0.57 mL 1.13 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838


If you know of a relevant reference for Viomycin, please let us know.

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1 Citation for Viomycin

Citations are publications that use Tocris products. Selected citations for Viomycin include:

Samokhvalov et al (2015) PPARĪ“ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478


Do you know of a great paper that uses Viomycin from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

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