Viomycin
Biological Activity
Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 881.85 |
| Formula | C25H43N13O10.2H2SO4 |
| Storage | Store at -20°C |
| CAS Number | 32988-50-4 |
| PubChem ID | 90488875 |
| InChI Key | HMKHTQGEDRQEOM-IGZVKJTASA-N |
| Smiles | O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 66.14 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 881.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.13 mL | 5.67 mL | 11.34 mL |
| 5 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 10 mM | 0.11 mL | 0.57 mL | 1.13 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.23 mL |
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References
References are publications that support the biological activity of the product.
Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906
Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509
Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838
If you know of a relevant reference for Viomycin, please let us know.
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2 Citations for Viomycin
Citations are publications that use Tocris products. Selected citations for Viomycin include:
Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478
Akbergenov et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Agents Chemother 55 4712 PMID: 21768509
Do you know of a great paper that uses Viomycin from Tocris? Please let us know.
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