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Submit ReviewViomycin
Description: Antibiotic; inhibits bacterial DNA synthesis
Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Biological Activity for Viomycin
Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Viomycin
| M. Wt | 881.85 |
| Formula | C25H43N13O10.2H2SO4 |
| Storage | Store at -20°C |
| PubChem ID | 90488875 |
| InChI Key | HMKHTQGEDRQEOM-IGZVKJTASA-N |
| Smiles | O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Viomycin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 66.14 | 75 |
Preparing Stock Solutions for Viomycin
The following data is based on the product molecular weight 881.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 1.51 mL | 7.56 mL | 15.12 mL |
| 3.75 mM | 0.3 mL | 1.51 mL | 3.02 mL |
| 7.5 mM | 0.15 mL | 0.76 mL | 1.51 mL |
| 37.5 mM | 0.03 mL | 0.15 mL | 0.3 mL |
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Product Datasheets for Viomycin
References for Viomycin
References are publications that support the biological activity of the product.
Ermolenko et al (2007) The antibiotic vio. traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906
Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509
Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838
If you know of a relevant reference for Viomycin, please let us know.
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Keywords: Viomycin, Viomycin supplier, Viomycin, disulfate, Pfizer, antibiotics, inhibits, inhibitors, bacterial, DNA, synthesis, 37883-00-4, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 3787, Tocris Bioscience
5 Citations for Viomycin
Citations are publications that use Tocris products. Selected citations for Viomycin include:
Abad et al (2018) Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer. Mol Cell Proteomics PMID: 30373788
Freihofer et al (2016) Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. RNA 22 1836 PMID: 27698071
Matilde E et al (2019) Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. Mol Cell Proteomics 18 231-244 PMID: 33451433
Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478
Akbergenov et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreo. and vio. Antimicrob Agents Chemother 55 4712 PMID: 21768509
Do you know of a great paper that uses Viomycin from Tocris? Please let us know.
Reviews for Viomycin
Average Rating: 4 (Based on 1 Review.)
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Viomycin and streptomycin were compared in inhibition of bacterial protein production.
By
Anonymous on 02/13/2019
Species: Human
Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.
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