Covidcil-19

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Description: Binds to SARS-CoV-2 frameshifting element and reduces frameshifting efficiency
Chemical Name: 3-[[4-(Methylamino)-2-quinazolinyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Covidcil-19

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

Technical Data for Covidcil-19

M. Wt 294.31
Formula C16H14N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1225177-95-6
PubChem ID 52108194
InChI Key ATKIOCNKZKNVQS-UHFFFAOYSA-N
Smiles CNC1=NC(NC2=CC(C(O)=O)=CC=C2)=NC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Covidcil-19

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.94 10

Preparing Stock Solutions for Covidcil-19

The following data is based on the product molecular weight 294.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.98 mL 169.89 mL 339.78 mL
0.5 mM 6.8 mL 33.98 mL 67.96 mL
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL

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References for Covidcil-19

References are publications that support the biological activity of the product.

Haniff et al (2020) Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders. ACS Cent.Sci. 6 1713 PMID: 33140033

Giorgio et al (2020) New chemical modalities enabling specific RNA targeting and degradation: application to SARS-CoV-2 RNA. ACS Cent.Sci. 6 1647 PMID: 33140031


If you know of a relevant reference for Covidcil-19, please let us know.

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Keywords: Covidcil-19, Covidcil-19 supplier, high, affinity, revised, attenuator, hairpin, structure, SARS-CoV-2, frameshifting, element, FSE, reduces, efficiency, COVID-19, DNA,, RNA, and, Protein, Synthesis, Coronavirus, 7485, Tocris Bioscience

Citations for Covidcil-19

Citations are publications that use Tocris products.

Currently there are no citations for Covidcil-19. Do you know of a great paper that uses Covidcil-19 from Tocris? Please let us know.

Reviews for Covidcil-19

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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