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Biological Activity for Covidcil-19
Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
Technical Data for Covidcil-19
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Covidcil-19
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Covidcil-19
The following data is based on the product molecular weight 294.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||33.98 mL||169.89 mL||339.78 mL|
|0.5 mM||6.8 mL||33.98 mL||67.96 mL|
|1 mM||3.4 mL||16.99 mL||33.98 mL|
|5 mM||0.68 mL||3.4 mL||6.8 mL|
References for Covidcil-19
References are publications that support the biological activity of the product.
Haniff et al (2020) Targeting the SARS-CoV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders. ACS Cent.Sci. 6 1713 PMID: 33140033
Giorgio et al (2020) New chemical modalities enabling specific RNA targeting and degradation: application to SARS-CoV-2 RNA. ACS Cent.Sci. 6 1647 PMID: 33140031
If you know of a relevant reference for Covidcil-19, please let us know.
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Citations for Covidcil-19
Citations are publications that use Tocris products.
Currently there are no citations for Covidcil-19. Do you know of a great paper that uses Covidcil-19 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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