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Description: Purine nuceloside analog; inhibits DNA synthesis
Alternative Names: GW 506U78
Chemical Name: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Nelarabine

Nelarabine is a nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.

Compound Libraries for Nelarabine

Nelarabine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nelarabine

M. Wt 297.27
Formula C11H15N5O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 121032-29-9
PubChem ID 3011155
Smiles COC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C=N2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nelarabine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.73 100
water 2.97 10 with gentle warming

Preparing Stock Solutions for Nelarabine

The following data is based on the product molecular weight 297.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for Nelarabine

References are publications that support the biological activity of the product.

Lambe et al (1995) 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 55 3352 PMID: 7614470

Beesley et al (2007) In vitro cytotoxicity of nelarabine, clofar. and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 137 109 PMID: 17391490

Reilly and Kisor et al (2009) Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2 219 PMID: 20616909

If you know of a relevant reference for Nelarabine, please let us know.

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Keywords: Nelarabine, Nelarabine supplier, GW506U78, nucleoside, analogs, analogues, prodrugs, purine, antimetabolites, ara-GTP, chemotherapeutics, GW, 506U78, DNA,, RNA, and, Protein, Synthesis, 6359, Tocris Bioscience

Citations for Nelarabine

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Currently there are no citations for Nelarabine. Do you know of a great paper that uses Nelarabine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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