Nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||2.97||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 297.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.36 mL||16.82 mL||33.64 mL|
|5 mM||0.67 mL||3.36 mL||6.73 mL|
|10 mM||0.34 mL||1.68 mL||3.36 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
References are publications that support the biological activity of the product.
Lambe et al (1995) 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 55 3352 PMID: 7614470
Beesley et al (2007) In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 137 109 PMID: 17391490
Reilly and Kisor et al (2009) Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2 219 PMID: 20616909
If you know of a relevant reference for Nelarabine, please let us know.
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