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Cat.No. 6359 - Nelarabine | C11H15N5O5 | CAS No. 121032-29-9
Description: Purine nuceloside analog; inhibits DNA synthesis
Alternative Names: GW 506U78
Chemical Name: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Purity: ≥98% (HPLC)

Biological Activity

Nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.

Technical Data

M. Wt 297.27
Formula C11H15N5O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 121032-29-9
PubChem ID 3011155
Smiles COC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C=N2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.73 100
water 2.97 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 297.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Lambe et al (1995) 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 55 3352 PMID: 7614470

Beesley et al (2007) In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 137 109 PMID: 17391490

Reilly and Kisor et al (2009) Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2 219 PMID: 20616909

If you know of a relevant reference for Nelarabine, please let us know.

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis