Nelarabine

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Cat.No. 6359 - Nelarabine | C11H15N5O5 | CAS No. 121032-29-9
Description: Purine nuceloside analog; inhibits DNA synthesis
Alternative Names: GW 506U78
Chemical Name: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.

Technical Data

M. Wt 297.27
Formula C11H15N5O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 121032-29-9
PubChem ID 3011155
InChI Key IXOXBSCIXZEQEQ-UHTZMRCNSA-N
Smiles COC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C=N2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.73 100
water 2.97 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 297.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References

References are publications that support the biological activity of the product.

Lambe et al (1995) 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 55 3352 PMID: 7614470

Beesley et al (2007) In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 137 109 PMID: 17391490

Reilly and Kisor et al (2009) Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2 219 PMID: 20616909


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Keywords: Nelarabine, Nelarabine supplier, GW506U78, nucleoside, analogs, analogues, prodrugs, purine, antimetabolites, ara-GTP, chemotherapeutics, GW, 506U78, DNA,, RNA, and, Protein, Synthesis, 6359, Tocris Bioscience

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Literature in this Area

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Cancer

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A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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