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Description: Selective exportin-1 (XPO1/CRM1) inhibitor
Chemical Name: (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Verdinexor

Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro, including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo. In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.

Technical Data for Verdinexor

M. Wt 442.32
Formula C18H12F6N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1392136-43-4
PubChem ID 71492799
Smiles C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C(NNC3=CC=CC=N3)=O)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Verdinexor

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.23 100
ethanol 2.21 5

Preparing Stock Solutions for Verdinexor

The following data is based on the product molecular weight 442.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.3 mL 22.61 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for Verdinexor

References are publications that support the biological activity of the product.

Pan (2021) XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor. J.Exp.Clin.Cancer Res. 40 255 PMID: 34384466

Perwitasari et al (2014) Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo J.Virol. 88 10228 PMID: 24965445

If you know of a relevant reference for Verdinexor, please let us know.

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