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Biological Activity for Verdinexor
Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro, including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo. In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.
Technical Data for Verdinexor
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Verdinexor
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Verdinexor
The following data is based on the product molecular weight 442.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.26 mL||11.3 mL||22.61 mL|
|5 mM||0.45 mL||2.26 mL||4.52 mL|
|10 mM||0.23 mL||1.13 mL||2.26 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References for Verdinexor
References are publications that support the biological activity of the product.
Pan (2021) XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor. J.Exp.Clin.Cancer Res. 40 255 PMID: 34384466
Perwitasari et al (2014) Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo J.Virol. 88 10228 PMID: 24965445
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Citations for Verdinexor
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Literature in this Area
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