Oxaliplatin

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Cat.No. 2623 - Oxaliplatin | C8H14N2O4Pt | CAS No. 61825-94-3
Description: DNA cross-linking antitumor agent
Alternative Names: Eloxatin
Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Literature
Pathways

Biological Activity

Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Technical Data

M. Wt 397.29
Formula C8H14N2O4Pt
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 61825-94-3
PubChem ID 9887054
InChI Key ZROHGHOFXNOHSO-BNTLRKBRSA-L
Smiles [Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.99 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 397.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.59 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Culy et al (2000) Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs 60 895 PMID: 11085200

Raymond et al (2002) Cellular and molecular pharmacology of oxaliplatin. Mol.Cancer Ther. 1 227 PMID: 12467217

Mani et al (2002) Oxaliplatin: a review of evolving concepts. Cancer Invest. 20 246 PMID: 11901545


If you know of a relevant reference for Oxaliplatin, please let us know.

Keywords: Oxaliplatin, supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducers, platinum-DNA, adducts, chemotherapeutics, Eloxatin, Apoptosis, Inducers, DNA,, RNA, and, Protein, Synthesis, Apoptosis, Inducers, Tocris Bioscience

6 Citations for Oxaliplatin

Citations are publications that use Tocris products. Selected citations for Oxaliplatin include:

Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306 PMID: 26218638

Fukushima et al (2015) Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci 106 1000 PMID: 26017781

Li et al (2015) FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. BMC Cancer 6 9240 PMID: 25860929

Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Exp Neurol 14 570 PMID: 25104095

Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359 PMID: 22256970

Boyette-Davis and Dougherty (2011) Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline. Oncotarget 229 353 PMID: 21385581


Do you know of a great paper that uses Oxaliplatin from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Oxaliplatin

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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