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Description: DNA cross-linking antitumor agent
Alternative Names: Eloxatin
Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity: ≥99% (HPLC)
Citations (7)
Reviews (2)
Literature (1)
Pathways (1)

Biological Activity for Oxaliplatin

Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Technical Data for Oxaliplatin

M. Wt 397.29
Formula C8H14N2O4Pt
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 61825-94-3
PubChem ID 9887054
Smiles [Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Oxaliplatin

Solvent Max Conc. mg/mL Max Conc. mM
water 1.99 5 with gentle warming

Preparing Stock Solutions for Oxaliplatin

The following data is based on the product molecular weight 397.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 50.34 mL 251.71 mL 503.41 mL
0.25 mM 10.07 mL 50.34 mL 100.68 mL
0.5 mM 5.03 mL 25.17 mL 50.34 mL
2.5 mM 1.01 mL 5.03 mL 10.07 mL

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Product Datasheets for Oxaliplatin

Certificate of Analysis / Product Datasheet
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References for Oxaliplatin

References are publications that support the biological activity of the product.

Culy et al (2000) Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs 60 895 PMID: 11085200

Raymond et al (2002) Cellular and molecular pharmacology of oxalip. Mol.Cancer Ther. 1 227 PMID: 12467217

Mani et al (2002) Oxaliplatin: a review of evolving concepts. Cancer Invest. 20 246 PMID: 11901545

If you know of a relevant reference for Oxaliplatin, please let us know.

Keywords: Oxaliplatin, Oxaliplatin supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducers, platinum-DNA, adducts, chemotherapeutics, Eloxatin, DNA,, RNA, and, Protein, Synthesis, 2623, Tocris Bioscience

7 Citations for Oxaliplatin

Citations are publications that use Tocris products. Selected citations for Oxaliplatin include:

Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Exp Neurol 14 570 PMID: 25104095

Li et al (2015) FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. BMC Cancer 6 9240 PMID: 25860929

Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306 PMID: 26218638

Fukushima et al (2015) Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci 106 1000 PMID: 26017781

Do you know of a great paper that uses Oxaliplatin from Tocris? Please let us know.

Reviews for Oxaliplatin

Average Rating: 5 (Based on 2 Reviews.)

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Oxaliplatin induced immunogenic cell death in HCT116 cells.
By Tahmineh Safaie on 02/28/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HCT116

HCT116 cells were treated with 600 uM of Oxaliplatin for 4 hours and up regulation of surface expression of calreticulin was measured.

review image

Oxaliplatin effectively kills melanoma cell growth in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Oxaliplatin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Oxaliplatin

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.