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Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. Production of cells identical to the parent is termed 'self-renewal.' Unlike other cell types, stem cells have the ability to replicate many times.
|Cat. No.||Product Name / Activity|
|Potent AMPK activator; inhibits MSC proliferation|
|Selective inhibitor of TGF-βRI, ALK4 and ALK7; maintains self-renewal of human iPSCs|
|Selectively eliminates NSCs in hESC-derived cell populations; also broad-spectrum ion channel blocker|
|Maintains self-renewal and pluripotency of ESCs; potent inhibitor of GSK-3; also inhibits cdks|
|AhR antagonist; promotes expansion of human hematopoietic stem cells|
|4027||16,16-Dimethyl Prostaglandin E2|
|Induces stem cell proliferation|
|Increases number of viable HSC during harvesting; DPP-IV inhibitor|
|Suppresses spontaneous differentiation of human ESCs; adenosine deaminase inhibitor|
|Negative control for ELA-32 (Cat.No.6291)|
|Apelin receptor agonist; promotes self-renewal and primes hESCs toward endoderm lineage|
|Converts epiblast stem cells to ESCs and promotes ESC self-renewal; CK1 inhibitor|
|Promotes expansion of human HSCs; PCAF/p300 HAT inhibitor|
|Antibiotic; activates short-term renewal of ESCs|
|Optimizes naïve human pluripotent stem cell growth and viability; PKC inhibitor|
|2910||H 89 dihydrochloride|
|Improves survival and clonogenicity of dissociated human ESCs; PKA inhibitor|
|E2F transcription factor inhibitor; attenuates hESC proliferation|
|Sustains self-renewal and pluripotency of ESCs|
|Dyrk1A/B inhibitor; impairs self-renewal of NSCs|
|Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation|
|PORCN inhibitor; suppresses self-renewal in R1 ESCs|
|6797||KLD 12 New|
|Self-assembling peptide; forms hydrogel to support cell growth|
|1130||LY 294002 hydrochloride|
|Prototypical PI 3-kinase inhibitor; suppresses proliferation of mESCs|
|Promotes HSC expansion; also FBPase inhibitor|
|5779||NSC 23005 sodium|
|Potently promotes HSC expansion ; p18INK inhibitor|
|Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors|
|MEK inhibitor; enhances ESC self-renewal|
|Acts synergistically with Y-27632 (Cat.No. 1254) to improve PSC cloning efficiency; PPARγ agonist|
|Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal|
|Induces hematopoietic stem cell proliferation|
|Enhances survival of human ESCs following enzymatic dissociation|
|Promotes stability of human PSCs; potent, selective inhibitor of p38 MAPK|
|Selective inhibitor of p38 MAPK; stimulates neural stem cell proliferation|
|GSK-3 inhibitor; maintains mouse ESCs in a pluripotent state|
|Induces proliferation, differentiation and sheet formation of ESC-derived endothelial cells|
|Stimulates short-term renewal of human ESCs in vitro|
|Supports mESC self-renewal; potent FGFR and VEGFR inhibitor|
|Maintains pluripotency of hESCs; heparin sulfate antagonist|
|High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation|
|Promotes hESC self-renewal|
|Improves survival of hESCs; ROCK inhibitor|
|Selective PPARγ agonist; inhibits growth of hematopoietic cell lines|
|Regulates hPSCs self-renewal; also potent, selective inhibitor of MEK1 and 2|
|Supports self-renewal of naive hESCs|
|Selective p160ROCK inhibitor; increases survival rate of human embryonic stem cells undergoing cryopreservation|
|Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity|
Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. The production of cells identical to the parent is termed 'self-renewal'. Proliferation and self-renewal are controlled by signaling molecules, growth factors and transcription factors.
Unlike other cell types such as muscle or blood cells, stem cells proliferate often as they have the ability to replicate many times. In fact, starting populations of stem cells can proliferate for many months in culture, finally yielding millions of cells. Often stem cell proliferation continues without differentiation and specialization over long periods: this is known as long-term self-renewal.
The ability of stem cells to proliferate may be beneficial in regenerative medicine. However, pathologically, the excessive proliferation of cancer stem cells can lead to the formation of tumors.
Tocris offers the following scientific literature for Stem Cell Proliferation to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.