Stem Cell Proliferation
Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. Production of cells identical to the parent is termed 'self-renewal.' Unlike other cell types, stem cells have the ability to replicate many times.
| Cat. No. | Product Name / Activity |
|---|---|
| 3336 | A 769662 |
| Potent AMPK activator; inhibits MSC proliferation | |
| 2939 | A 83-01 |
| Selective inhibitor of TGF-βRI, ALK4 and ALK7; maintains self-renewal of human iPSCs | |
| 4095 | Amiodarone hydrochloride |
| Selectively eliminates NSCs in hESC-derived cell populations; also broad-spectrum ion channel blocker | |
| 3194 | BIO |
| Maintains self-renewal and pluripotency of ESCs; potent inhibitor of GSK-3; also inhibits cdks | |
| 3858 | CH 223191 |
| AhR antagonist; promotes expansion of human hematopoietic stem cells | |
| 4027 | 16,16-Dimethyl Prostaglandin E2 |
| Induces stem cell proliferation | |
| 6019 | Diprotin A |
| Increases number of viable HSC during harvesting; DPP-IV inhibitor | |
| 1261 | EHNA hydrochloride |
| Suppresses spontaneous differentiation of human ESCs; adenosine deaminase inhibitor | |
| 6292 | ELARR>GG |
| Negative control for ELA-32 (Cat.No.6291) | |
| 6291 | ELA-32 (human) |
| Apelin receptor agonist; promotes self-renewal and primes hESCs toward endoderm lineage | |
| 6340 | Epiblastin A |
| Converts epiblast stem cells to ESCs and promotes ESC self-renewal; CK1 inhibitor | |
| 6961 | FzM1.8 New |
| Preserves stemness and promotes proliferation of undifferentiated cells; Frizzled 4 allosteric agonist | |
| 3849 | Gatifloxacin |
| Antibiotic; activates short-term renewal of ESCs | |
| 2285 | Go 6983 |
| Optimizes naïve human pluripotent stem cell growth and viability; PKC inhibitor | |
| 2910 | H 89 dihydrochloride |
| Improves survival and clonogenicity of dissociated human ESCs; PKA inhibitor | |
| 5283 | HLM 006474 |
| E2F transcription factor inhibitor; attenuates hESC proliferation | |
| 3853 | ID 8 |
| Sustains self-renewal and pluripotency of ESCs | |
| 4997 | INDY |
| Dyrk1A/B inhibitor; impairs self-renewal of NSCs | |
| 4713 | IQ 1 |
| Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation | |
| 5284 | trans-ISRIB |
| Promotes survival of hPSCs in combination with other small molecules; also integrated stress response (ISR) inhibitor | |
| 3533 | IWP 2 |
| PORCN inhibitor; suppresses self-renewal in R1 ESCs | |
| 6797 | KLD 12 New |
| Self-assembling peptide; forms hydrogel to support cell growth | |
| 1130 | LY 294002 hydrochloride |
| Prototypical PI 3-kinase inhibitor; suppresses proliferation of mESCs | |
| 6618 | MB 05032 |
| Promotes HSC expansion; also FBPase inhibitor | |
| 5779 | NSC 23005 sodium |
| Potently promotes HSC expansion ; p18INK inhibitor | |
| 1671 | PD 102807 |
| Promotes expansion of erythroid progenitors | |
| 3044 | PD 173074 |
| Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors | |
| 1213 | PD 98059 |
| MEK inhibitor; enhances ESC self-renewal | |
| 4124 | Pioglitazone hydrochloride |
| Acts synergistically with Y-27632 (Cat.No. 1254) to improve PSC cloning efficiency; PPARγ agonist | |
| 4433 | Pluripotin |
| Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal | |
| 6991 | Poly Vinyl Alcohol New |
| Carrier molecule for stem cell culture; replaces serum albumin for ex vivo stem cell expansion | |
| 2296 | Prostaglandin E2 |
| Induces hematopoietic stem cell proliferation | |
| 4978 | Pyrintegrin |
| Enhances survival of human ESCs following enzymatic dissociation | |
| 1264 | SB 202190 |
| Promotes stability of human PSCs; potent, selective inhibitor of p38 MAPK | |
| 1202 | SB 203580 |
| Selective inhibitor of p38 MAPK; stimulates neural stem cell proliferation | |
| 1616 | SB 216763 |
| GSK-3 inhibitor; maintains mouse ESCs in a pluripotent state | |
| 1614 | SB 431542 |
| Induces proliferation, differentiation and sheet formation of ESC-derived endothelial cells | |
| 3784 | Sildenafil citrate |
| Promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100; potent PDE5 inhibitor | |
| 3848 | Sinomenine hydrochloride |
| Stimulates short-term renewal of human ESCs in vitro | |
| 1496 | SP 600125 |
| Used for maintaining stem cells in naive pluripotent state; selective JNK inhibitor | |
| 3300 | SU 5402 |
| Supports mESC self-renewal; potent FGFR and VEGFR inhibitor | |
| 6634 | Surfen |
| Maintains pluripotency of hESCs; heparin sulfate antagonist | |
| 5759 | SW 033291 |
| High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation | |
| 3847 | Theanine |
| Promotes hESC self-renewal; glutamate receptor ligand | |
| 3845 | Thiazovivin |
| Improves survival of hESCs; ROCK inhibitor | |
| 3114 | Troglitazone |
| Selective PPARγ agonist; inhibits growth of hematopoietic cell lines | |
| 1144 | U0126 |
| Regulates hPSCs self-renewal; also potent, selective inhibitor of MEK1 and 2 | |
| 5413 | WH-4-023 |
| Supports self-renewal of naive hESCs | |
| 1254 | Y-27632 dihydrochloride |
| Selective ROCK inhibitor; increases survival rate of human embryonic stem cells undergoing cryopreservation | |
| 6719 | YH 239-EE |
| Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity |
Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. The production of cells identical to the parent is termed 'self-renewal'. Proliferation and self-renewal are controlled by signaling molecules, growth factors and transcription factors.
Unlike other cell types such as muscle or blood cells, stem cells proliferate often as they have the ability to replicate many times. In fact, starting populations of stem cells can proliferate for many months in culture, finally yielding millions of cells. Often stem cell proliferation continues without differentiation and specialization over long periods: this is known as long-term self-renewal.
The ability of stem cells to proliferate may be beneficial in regenerative medicine. However, pathologically, the excessive proliferation of cancer stem cells can lead to the formation of tumors.
Literature for Stem Cell Proliferation
Tocris offers the following scientific literature for Stem Cell Proliferation to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Our Cancer Research Guide highlights over 750 products for cancer research.
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Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming.
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Developed in-house, this poster summarizes how small molecules have been used in protocols across the stem cell workflow.
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Written by Rebecca Quelch and Stefan Przyborski, this poster summarizes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and potential uses.
Request copyDownload PDF