Stem Cell Proliferation

Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. Production of cells identical to the parent is termed 'self-renewal.' Unlike other cell types, stem cells have the ability to replicate many times.

Products
Background
Literature
Cat No Product Name / Activity
3336 A 769662
Potent AMPK activator; inhibits MSC proliferation
2939 A 83-01
Selective inhibitor of TGF-βRI, ALK4 and ALK7; maintains self-renewal of human iPSCs
4095 Amiodarone hydrochloride
Selectively eliminates NSCs in hESC-derived cell populations; also broad-spectrum ion channel blocker
3194 BIO
Potent, selective GSK-3 inhibitor; maintains self-renewal and pluripotency of ESCs
3858 CH 223191
AhR antagonist; promotes expansion of human hematopoietic stem cells
5702 DiD perchlorate
Lipophilic fluorescent reagent; shown to stain HSCs
4027 16,16-Dimethyl Prostaglandin E2
Induces stem cell proliferation
6019 Diprotin A
Increases number of viable HSC during harvesting; DPP-IV inhibitor
1261 EHNA hydrochloride
Suppresses spontaneous differentiation of human ESCs; adenosine deaminase inhibitor
6292 ELARR>GG
Negative control for ELA-32 (Cat.No.6291)
6291 ELA-32 (human)
Apelin receptor agonist; promotes self-renewal and primes hESCs toward endoderm lineage
4827 Garcinol
Promotes expansion of human HSCs; PCAF/p300 HAT inhibitor
3849 Gatifloxacin
Antibiotic; activates short-term renewal of ESCs
2285 Go 6983
Optimizes naïve human pluripotent stem cell growth and viability; PKC inhibitor
5283 HLM 006474
E2F transcription factor inhibitor; attenuates hESC proliferation
3853 ID 8
Sustains self-renewal and pluripotency of ESCs
4997 INDY
Dyrk1A/B inhibitor; impairs self-renewal of NSCs
4713 IQ 1
Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation
3533 IWP 2
PORCN inhibitor; suppresses self-renewal in R1 ESCs
1130 LY 294002 hydrochloride
Prototypical PI 3-kinase inhibitor; suppresses proliferation of mESCs
5779 NSC 23005 sodium
Potently promotes HSC expansion ; p18INK inhibitor
3044 PD 173074
Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors
1213 PD 98059
MEK inhibitor; enhances ESC self-renewal
4433 Pluripotin
Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
2296 Prostaglandin E2
Induces hematopoietic stem cell proliferation
4978 Pyrintegrin
Enhances survival of human ESCs following enzymatic dissociation
1264 SB 202190
Promotes stability of human PSCs; potent, selective inhibitor of p38 MAPK
1202 SB 203580
Selective inhibitor of p38 MAPK; stimulates neural stem cell proliferation
1616 SB 216763
GSK-3 inhibitor; maintains mouse ESCs in a pluripotent state
1614 SB 431542
Induces proliferation, differentiation and sheet formation of ESC-derived endothelial cells
3848 Sinomenine hydrochloride
Stimulates short-term renewal of human ESCs in vitro
5759 SW 033291
High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
3847 Theanine
Promotes hESC self-renewal
3114 Troglitazone
Selective PPARγ agonist; inhibits growth of hematopoietic cell lines
1144 U0126
Regulates hPSCs self-renewal; also potent, selective inhibitor of MEK1 and 2
5413 WH-4-023
Supports self-renewal of naive hESCs
1254 Y-27632 dihydrochloride
Selective p160ROCK inhibitor; increases survival rate of human embryonic stem cells undergoing cryopreservation

Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. The production of cells identical to the parent is termed 'self-renewal'. Proliferation and self-renewal are controlled by signaling molecules, growth factors and transcription factors.

Unlike other cell types such as muscle or blood cells, stem cells proliferate often as they have the ability to replicate many times. In fact, starting populations of stem cells can proliferate for many months in culture, finally yielding millions of cells. Often stem cell proliferation continues without differentiation and specialization over long periods: this is known as long-term self-renewal.

The ability of stem cells to proliferate may be beneficial in regenerative medicine. However, pathologically, the excessive proliferation of cancer stem cells can lead to the formation of tumors.

Literature for Stem Cell Proliferation

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.