Home / Pharmacology / Enzymes / Kinases / Casein Kinase 1 / Casein Kinase 1 Inhibitors / Epiblastin A

Epiblastin A

Cat. No. 6340 Submit a Review Datasheet / COA / SDS

Discontinued Product

6340 has been discontinued.

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Description: CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
Chemical Name: 6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Epiblastin A

Epiblastin A is a CK1 inhibitor (IC50 values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.

Compound Libraries for Epiblastin A

Epiblastin A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Epiblastin A

M. Wt 287.71
Formula C12H10CIN7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 16470-02-3
PubChem ID 118987042
InChI Key ZWNKKZSRANLVEW-UHFFFAOYSA-N
Smiles NC1=NC2=NC(N)=C(C3=CC(Cl)=CC=C3)N=C2C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Epiblastin A

References are publications that support the biological activity of the product.

Illich et al (2016) Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 15 787 PMID: 27149845

Ursu et al (2016) Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 23 494 PMID: 27049670

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Citations for Epiblastin A

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Currently there are no citations for Epiblastin A.

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Literature in this Area

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