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CK1 inhibitor (IC50 values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 287.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||17.38 mL||86.89 mL||173.79 mL|
|1 mM||3.48 mL||17.38 mL||34.76 mL|
|2 mM||1.74 mL||8.69 mL||17.38 mL|
|10 mM||0.35 mL||1.74 mL||3.48 mL|
References are publications that support the biological activity of the product.
Illich et al (2016) Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 15 787 PMID: 27149845
Ursu et al (2016) Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 23 494 PMID: 27049670
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Keywords: Epiblastin A, Epiblastin A supplier, EpiblastinA, CK1, inhibitors, inhibits, casein, kinase, Epiblast, stem, cells, conversion, pluripotency, self, renewal, Casein, Kinase, 1, Stem, Cell, Proliferation, Reprogramming, 6340, Tocris Bioscience
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