Epiblastin A

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Cat.No. 6340 - Epiblastin A | C12H10ClN7 | CAS No. 16470-02-3
Description: CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
Chemical Name: 6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

CK1 inhibitor (IC50 values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.

Technical Data

M. Wt 287.71
Formula C12H10CIN7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 16470-02-3
PubChem ID 118987042
InChI Key ZWNKKZSRANLVEW-UHFFFAOYSA-N
Smiles NC1=NC2=NC(N)=C(C3=CC(Cl)=CC=C3)N=C2C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.75 20

Preparing Stock Solutions

The following data is based on the product molecular weight 287.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.38 mL 86.89 mL 173.79 mL
1 mM 3.48 mL 17.38 mL 34.76 mL
2 mM 1.74 mL 8.69 mL 17.38 mL
10 mM 0.35 mL 1.74 mL 3.48 mL

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References

References are publications that support the biological activity of the product.

Illich et al (2016) Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 15 787 PMID: 27149845

Ursu et al (2016) Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 23 494 PMID: 27049670


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View all Casein Kinase 1 Inhibitors

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Citations for Epiblastin A

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