EHNA hydrochloride

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Cat.No. 1261 - EHNA hydrochloride | C14H23N5O.HCl | CAS No. 58337-38-5
Description: Adenosine deaminase inhibitor
Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (11)
Reviews
Literature (1)

Biological Activity

Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

Technical Data

M. Wt 313.83
Formula C14H23N5O.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 58337-38-5
PubChem ID 11056106
InChI Key VVDXNJRUNJMYOZ-DHXVBOOMSA-N
Smiles NC1=NC=NC2=C1N=CN2[C@@H](CCCCCC)[C@H](O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.38 100
ethanol 31.38 100
DMSO 31.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 313.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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View all Deaminase Inhibitors

Keywords: EHNA hydrochloride, EHNA hydrochloride supplier, PDE2, inhibitors, inhibits, adenosines, deaminases, Phosphodiesterases, Deaminases, Other, Adenosine, Stem, Cell, Proliferation, 1261, Tocris Bioscience

11 Citations for EHNA hydrochloride

Citations are publications that use Tocris products. Selected citations for EHNA hydrochloride include:

Yang et al (2010) Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40 449 PMID: 19950175

Xiao et al (2019) Physiology and effects of nucleosides in mice lacking all four adenosine receptors. PLoS Biol 17 e3000161 PMID: 30822301

Uckert (2001) Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate. J Urol 166 2484 PMID: 11696815

Lindquist (2012) Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices. Neuroscience 223 365 PMID: 22864185


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Literature in this Area

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