EHNA hydrochloride

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Description: Adenosine deaminase inhibitor
Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride
Purity: ≥98% (HPLC)
Citations (11)

Biological Activity for EHNA hydrochloride

EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

Compound Libraries for EHNA hydrochloride

EHNA hydrochloride is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for EHNA hydrochloride

M. Wt 313.83
Formula C14H23N5O.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 58337-38-5
PubChem ID 11056106
Smiles NC1=NC=NC2=C1N=CN2[C@@H](CCCCCC)[C@H](O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EHNA hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 31.38 100
ethanol 31.38 100
DMSO 31.38 100

Preparing Stock Solutions for EHNA hydrochloride

The following data is based on the product molecular weight 313.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for EHNA hydrochloride

Certificate of Analysis / Product Datasheet
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References for EHNA hydrochloride

References are publications that support the biological activity of the product.

Bessodes et al (1982) Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition. Biochem.Pharmacol. 31 879 PMID: 7082355

Michie et al (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell.Signal. 8 97 PMID: 8730511

Podzuweit et al (1995) Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine. Cell.Signal. 7 733 PMID: 8519602

If you know of a relevant reference for EHNA hydrochloride, please let us know.

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Keywords: EHNA hydrochloride, EHNA hydrochloride supplier, PDE2, inhibitors, inhibits, adenosines, deaminases, Phosphodiesterases, Deaminases, Other, Adenosine, Stem, Cell, Proliferation, 1261, Tocris Bioscience

11 Citations for EHNA hydrochloride

Citations are publications that use Tocris products. Selected citations for EHNA hydrochloride include:

Yu et al (2016) Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease. Mol Cell Proteomics 15 810 PMID: 26362317

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Am J Physiol Renal Physiol 3 e00121 PMID: 26038697

Prakasam et al (2012) Modulation of bladder function by luminal adenosine turnover and A1 receptor activation. PLoS One 303 F279 PMID: 22552934

Davidson et al (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One 11 e0158981 PMID: 27384524

Do you know of a great paper that uses EHNA hydrochloride from Tocris? Please let us know.

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