SW 033291

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Description: High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
Purity: ≥98% (HPLC)

Biological Activity for SW 033291

SW 033291 is a high affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

Compound Libraries for SW 033291

SW 033291 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SW 033291

M. Wt 412.59
Formula C21H20N2OS3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 459147-39-8
PubChem ID 3337839
Smiles NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SW 033291

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.26 100
ethanol 8.25 20

Preparing Stock Solutions for SW 033291

The following data is based on the product molecular weight 412.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for SW 033291

References are publications that support the biological activity of the product.

Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340 PMID: 26068857

If you know of a relevant reference for SW 033291, please let us know.

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Citations for SW 033291

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