SW 033291

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Cat.No. 5759 - SW 033291 | C21H20N2OS3 | CAS No. 459147-39-8
Description: High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

Technical Data

M. Wt 412.59
Formula C21H20N2OS3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 459147-39-8
PubChem ID 3337839
InChI Key LCYAYKSMOVLVRL-UHFFFAOYSA-N
Smiles NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.26 100
ethanol 8.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 412.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340 PMID: 26068857


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Citations for SW 033291

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