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SW 033291

Cat. No. 5759 Submit a Review Datasheet / COA / SDS

Discontinued Product

5759 has been discontinued.

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Description: High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
Chemical Name: 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for SW 033291

SW 033291 is a high affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

Compound Libraries for SW 033291

SW 033291 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SW 033291

M. Wt 412.59
Formula C21H20N2OS3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 459147-39-8
PubChem ID 3337839
InChI Key LCYAYKSMOVLVRL-UHFFFAOYSA-N
Smiles NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SW 033291

References are publications that support the biological activity of the product.

Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340 PMID: 26068857

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Citations for SW 033291

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