Diprotin A

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor
Alternative Names: Ile-Pro-Ile
Chemical Name: L-Isoleucyl-L-prolyl-L-isoleucine
Purity: ≥98% (HPLC)

Biological Activity for Diprotin A

Diprotin A is a dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.

Technical Data for Diprotin A

M. Wt 341.45
Formula C17H31N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 90614-48-5
PubChem ID 94701
Smiles O=C([C@@H](N)[C@@H](C)CC)N1[C@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Diprotin A

Solvent Max Conc. mg/mL Max Conc. mM
water 34.15 100

Preparing Stock Solutions for Diprotin A

The following data is based on the product molecular weight 341.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.64 mL 29.29 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Diprotin A

Certificate of Analysis / Product Datasheet
Select another batch:

References for Diprotin A

References are publications that support the biological activity of the product.

Juillerat-Jeanneret et al (2014) Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 57 2197 PMID: 24099035

Lim et al (2015) Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 30 759 PMID: 26552451

Lee et al (2016) Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 6 29393 PMID: 27381080

If you know of a relevant reference for Diprotin A, please let us know.

View Related Products by Product Action

View all Dipeptidyl Peptidase IV Inhibitors

Keywords: Diprotin A, Diprotin A supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, type, 2, diabetes, hematopoietic, stem, cells, HSCs, vascular, permeability, DPP4, haematopoietic, HSC, Ile-Pro-Ile, Dipeptidyl, Peptidase, (DPP-IV), Stem, Cell, Proliferation, Hematopoietic, Cells, 6019, Tocris Bioscience

Citations for Diprotin A

Citations are publications that use Tocris products.

Currently there are no citations for Diprotin A. Do you know of a great paper that uses Diprotin A from Tocris? Please let us know.

Reviews for Diprotin A

There are currently no reviews for this product. Be the first to review Diprotin A and earn rewards!

Have you used Diprotin A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review