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Cat.No. 7310 - Emricasan | C26H27F4N3O7 | CAS No. 254750-02-2
Description: Potent pan-caspase inhibitor
Chemical Name: N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity: ≥98% (HPLC)
Literature (7)

Biological Activity for Emricasan

Emricasan is a potent caspase inhibitor (IC50 values are 0.3, 0.4, 2, 4, 6, 6 and 20 nM for caspase-9, -1, -3, -6, -7, -8, and -2, respectively). Emricasan preserves cell viability after infection with several strains of Zika. Emricasan promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), trans-ISRIB (Cat. No. 5284) and polyamines, a combination known as CEPT. When used as part of the CEPT cocktail, Emricasan improves survival of differentiated cells following cryopreservation. The compound also reduces hepatic inflammation in an animal model of liver injury. Orally bioavailable.

Technical Data for Emricasan

M. Wt 569.51
Formula C26H27F4N3O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 254750-02-2
PubChem ID 12000240
Smiles N(C(C(N[C@H](C(N[C@H](C(COC1=C(F)C(F)=CC(F)=C1F)=O)CC(O)=O)=O)C)=O)=O)C2=C(C(C)(C)C)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Emricasan

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 56.95 100
ethanol 28.48 50

Preparing Stock Solutions for Emricasan

The following data is based on the product molecular weight 569.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.78 mL 17.56 mL
5 mM 0.35 mL 1.76 mL 3.51 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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References for Emricasan

References are publications that support the biological activity of the product.

Chen et al (2021) A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nat.Methods 18 528 PMID: 33941937

Canbay et al (2004) The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J.Pharmacol.Exp.Ther. 308 1191 PMID: 14617689

If you know of a relevant reference for Emricasan, please let us know.

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Keywords: Emricasan, Emricasan supplier, IDN6556, caspases, inhibitors, pluripotent, potent, stem, cells, CEPT, cryopreservation, differentiation, differentiated, zika, maintenance, self-renewal, orally, bioavailable, Caspases, Stem, Cell, Proliferation, 7310, Tocris Bioscience

Citations for Emricasan

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