Cell Adhesion Molecules

Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
6048 R-BC154
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs

Other

Cat No Product Name / Activity
2524 A 205804
Selective inhibitor of E-selectin and ICAM-1 expression
4228 A 286982
Potent inhibitor of the LFA-1/ICAM-1 interaction
1846 Ac2-12
Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
1845 Ac2-26
Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
3910 BIO 1211
Selective α4β1 (VLA-4) inhibitor
5051 BIO 5192
Highly potent and selective inhibitor of integrin α4β1
4776 BIRT 377
Potent negative allosteric modulator of LFA-1
6047 BOP
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
4724 BTT 3033
Selective inhibitor of integrin α2β1
5870 Cilengitide
Potent and selective inhibitor of integrins αvβ3 and αvβ5
3202 Echistatin, α1 isoform
Integrin αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
6102 Ep23, 5'-DY647
High affinity fluorescently tagged aptamer for EpCam
4725 Eptifibatide
Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation
1263 GR 144053 trihydrochloride
Glycoprotein IIb/IIIa (integrin αIIbβ3) antagonist. Antithrombotic
2812 Heparin sodium salt
Anticoagulant
2748 KF 38789
Selective inhibitor of P-selectin-mediated cell adhesion
4577 LDV FITC
Fluorescent ligand for α4β1 (VLA-4)
4921 Leukadherin 1
Allosteric activator of CD11b/CD18
2877 MNS
Glycoprotein IIb/IIIa (αIIbβ3) inhibitor. Also inhibits Src and Syk
4664 Obtustatin
Potent and selective α1β1 inhibitor
2710 OGT 2115
Heparanase inhibitor. Antiangiogenic
5760 P-3FAX-Neu5Ac
Sialic acid analog; reduces binding of E- and P-selectin
4744 P11
Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
4034 PM 102
Antagonist of heparin (Cat. No. 2812)
3498 RGDS peptide
Integrin binding sequence; inhibits integrin receptor function
4227 RWJ 50271
Inhibitor of LFA-1/ICAM mediated cell adhesion
4527 TC-I 15
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
3900 TCS 2314
α4β1 (VLA-4) antagonist
1567 Thiolutin
Antibiotic. Inhibits vitronectin cell adhesion

Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.

There are four major families of cell adhesion molecules:

  1. Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this family include neural cell adhesion molecule (NCAM) and intracellular adhesion molecule (ICAM).
  2. Selectins - Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).
  3. Integrins - bind IgSFs and extracellular matrix ligands (e.g. collagen, laminin) and regulate focal adhesion kinase and Src family kinase activity.
  4. Cadherins - Ca2+-dependent CAMs that are important in cell-cell junctions. Examples include E-cadherin (endothelial), P-cadherin (placental) and N-cadherin (neural).

Literature for Cell Adhesion Molecules

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Adhesion Molecule Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Immunoglobulins
NCAM1 Human NCAM1 NM_000615 Q59FL7
Mouse Ncam1 NM_001081445 P13595
Rat Ncam1 NM_031521 Q6LDL9
NCAM2 Human NCAM2 NM_004540 O15394
Mouse Ncam2 NM_010954 O35136
Rat Ncam2 NM_203409 Q6RKB2
ICAM1 Human ICAM1 NM_000201 P05362
Mouse Icam1 NM_010493 Q62470
Rat Icam1 NM_012967 Q00238
ICAM2 Human ICAM2 NM_001099787 P13598
Mouse Icam2 NM_010494 P35330
Rat Icam2 NM_001007725 Q6AXM6
ICAM3 Human ICAM3 NM_002162 P32942
ICAM4 Human ICAM4 NM_001039132 Q14773
Mouse Icam4 NM_023892 Q9ERM2
Rat Icam4 XM_233736 -
ICAM5 Human ICAM5 NM_003259 Q9UMF0
Mouse Icam5 NM_008319 Q60625
Rat Icam5 XM_233737 XP_233737
VCAM1 Human VCAM1 NM_001078 P19320
Mouse Vcam1 NM_011693 P29533
Rat Vcam1 NM_012889 P29534
PECAM1 Human PECAM1 NM_000442 Q9NQS9
Mouse Pecam1 NM_008816 Q08481
Rat Pecam1 NM_031591 Q3SWT0
Selectins
E-Selectin Human SELE NM_000450 P16581
Mouse Sele NM_011345 Q00690
Rat Sele NM_138879 P98105
L-Selectin Human SELL NM_000655 P14151
Mouse Sell NM_011346 P18337
Rat Sell NM_019177 P30836
P-Selectin Human SELP NM_003005 P16109
Mouse Selp NM_011347 Q01102
Rat Selp NM_013114 Q3MID1
Integrins
α1 Human ITGA1 NM_181501 P56199
Mouse Itga1 NM_001033228 Q3V3R4
Rat Itga1 NM_030994 P18614
α2 Human ITGA2 NM_002203 P17301
Mouse Itga2 NM_008396 Q62469
Rat Itga2 XM_345156 Q924S3
α3 Human ITGA3 NM_005501 P26006
Mouse Itga3 NM_013565 Q62470
Rat Itga3 NM_001108292 XP_340885
α4 Human IGTA4 NM_000885 P13612
Mouse Igta4 NM_010576 Q00651
Rat Igta4 NM_001107737 XP_230033
α5 Human ITGA5 NM_002205 P08648
Mouse Itga5 NM_010577 P11688
Rat Itga5 NM_001108118 Q7M074
α6 Human ITGA6 NM_001079818 Q53RX7
Mouse Itga6 NM_008397 Q61739
Rat Igta6 XM_215984 Q924W3
α7 Human ITGA7 NM_002206 Q13683
Mouse Itga7 NM_008398 Q61738
Rat Itga7 NM_030842 Q63258
α8 Human ITGA8 NM_003638 P53708
Mouse Itga8 NM_001001309 A2ARA8
Rat Itga8 AF148797 Q9WUP8
α9 Human ITGA9 NM_002207 Q13797
Mouse Itga9 NM_133721 NP_598482
Rat Itga9 XM_001061864 XP_001061864
α10 Human ITGA10 NM_003637 O75578
Mouse Itga10 NM_001081053 NP_001074522
Rat Itga10 NM_001107699 XP_227469
α11 Human ITGA11 NM_012211 Q9UKX5
Mouse Itga11 NM_176922 P61622
Rat Itga11 NM_001108156 XP_236320
αD Human ITGAD NM_005353 Q13349
Mouse Itgad NM_001029872 Q3V0T4
Rat Itgad NM_031691 Q9QYE7
αE Human ITGAE NM_002208 P38570
Mouse Itgae NM_008399 Q60677
Rat Itgae NM_031768 O88340
αL Human ITGAL NM_002209 P20701
Mouse Itgal NM_008400 P24063
Rat Itgal NM_001033998 Q3T1L6
αM Human ITGAM NM_000632 P11215
Mouse Itgam NM_001082960 P05555
Rat Igtam NM_012711 Q9JI30
αV Human ITGAV NM_002210 P06756
Mouse Itgav NM_008402 P43406
Rat Itgav NM_001106549 XP_230950
αX Human ITGAX NM_000887 P20702
Mouse Itgax NM_021334 Q9QXH4
Rat Itgax XM_574569 XP_574569
β1 Human ITGB1 NM_002211 Q14622
Mouse Itgb1 NM_010578 P09055
Rat Itgb1 NM_017022 P49134
β2 Human ITGB2 NM_000211 P05107
Mouse Itgb2 NM_008404 P11835
Rat Itgb2 NM_001037780 Q4KLK5
β3 Human ITGB3 NM_000212 P05106
Mouse Itgb3 NM_016780 O54890
Rat Itgb3 NM_153720 Q8R2H2
β4 Human ITGB4 NM_001005731 P16144
Mouse Itgb4 NM_001005608 NP_001005608
Rat Itgb4 NM_013180 Q64632
β5 Human ITGB5 NM_002213 P18084
Mouse Itgb5 NM_010580 O70309
Rat Itgb5 NM_147139.2 Q8VIM7
β6 Human ITGB6 NM_000888 P18564
Mouse Itgb6 NM_021359 Q9Z0T9
Rat Itgb6 NM_001004263 Q6AYF4
β7 Human ITGB7 NM_000889 P26010
Mouse Itgb7 NM_013566 P26011
Rat Itgb7 XM_343336 Q4G029
β8 Human ITGB8 NM_002214 P26012
Mouse Itgb8 NM_177290 NP_796264
Rat Itgb8 NM_001108726 XP_343127
Cadherins
E-cadherin
(Cadherin 1)
Human CDH1 NM_004360 P12830
Mouse Cdh1 NM_009864 P09803
Rat Cdh1 NM_031334 Q9R0T4
N-cadherin
(Cadherin 2)
Human CDH2 NM_001792 P19022
Mouse Cdh2 NM_007664 P15116
Rat Cdh2 NM_031333 Q9Z1Y3
P-cadherin
(Cadherin 3)
Human CDH3 NM_001793 P22223
Mouse Cdh3 NM_001037809 P10287
Rat Cdh3 XM_226426 Q9JIV6
R-cadherin
(Cadherin 4)
Human CDH4 NM_001794 P55283
Mouse Cdh4 NM_009867 P39038
Rat Cdh4 XM_230955 XP_230955
VE-cadherin
(Cadherin 5)
Human CDH5 NM_001795 P33151
Mouse Cdh5 NM_009868 P55284
Rat Cdh5 NM_001107407 XP_226213
K-cadherin
(Cadherin 6)
Human CDH6 NM_004932 P55285
Mouse Cdh6 NM_007666 P97326
Rat Cdh6 NM_012927 P55280
Cadherin 7 Human CDH7 NM_033646 Q9ULB5
Mouse Cdh7 NM_172853 Q8BM92
Rat Cdh7 NM_001012737 Q5DWV2
Cadherin 8 Human CDH8 NM_001796 P55286
Mouse Cdh8 NM_001039154 P97291
Rat Cdh8 NM_053393 O54800
T1-cadherin
(Cadherin 9)
Human CDH9 NM_016279 Q9ULB4
Mouse Cdh9 NM_009869 P70407
Rat Cdh9 XM_226861 XP_226861
T2-cadherin
(Cadherin 10)
Human CDH10 NM_006727 Q9Y6N8
Mouse Cdh10 NM_009865 P70408
Rat Cdh10 XM_342202 Q8R5H2
OB-cadherin
(Cadherin 11)
Human CDH11 NM_033664 P55287
Mouse Cdh11 NM_009866 P55288
Rat Cdh11 XM_341639 Q63760
N-cadherin 2
(Cadherin 12)
Human CDH12 NM_004061 P55289
Mouse Cdh12 NM_001008420 Q5RJH3
Rat Cdh12 XM_229369 XP_229369
H-cadherin
(Cadherin 13)
Human CDH13 NM_001257 P55290
Mouse Cdh13 NM_019707 Q9WTR5
Rat Cdh13 NM_138889 Q8R490
M-cadherin
(Cadherin 15)
Human CDH15 NM_004933 P55291
Mouse Cdh15 NM_007662 P33146
Rat Cdh15 NM_207613 Q75NI5
KSP-cadherin
(Cadherin 16)
Human CDH16 NM_004062 O75309
Mouse Cdh16 NM_007663 O88338
Rat Cdh16 NM_001012055 Q66H67
LI-cadherin
(Cadherin 17)
Human CDH17 NM_004063 Q12864
Mouse Cdh17 NM_019753 Q9R100
Rat Cdh17 NM_053977 P55281
Cadherin 18 Human CDH18 NM_004934 Q13634
Mouse Cdh18 NM_001081299 NP_001074768
Rat Cdh18 NM_001107656 XP_226899
Cadherin 19 Human CDH19 NM_021153 Q9H159
Mouse Cdh19 NM_001081386 NP_001074855
Rat Cdh19 NM_001009448 Q5NUI3
Cadherin 20 Human CDH20 NM_031891 Q9HBT6
Mouse Cdh20 NM_011800 Q9Z0M3
Rat Cdh20 NM_001012748 Q5DWV1