Cell Adhesion Molecules
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
Inhibitors |
|
|---|---|
| Cat No | Product Name / Activity |
| 4970 | BMS 688521New |
| Potent inhibitor of the LFA-1/ICAM-1 interaction | |
| 6048 | R-BC154 |
| High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs | |
Other |
|
| Cat No | Product Name / Activity |
| 2524 | A 205804 |
| Selective inhibitor of E-selectin and ICAM-1 expression | |
| 4228 | A 286982 |
| Potent inhibitor of the LFA-1/ICAM-1 interaction | |
| 1846 | Ac2-12 |
| Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | |
| 1845 | Ac2-26 |
| Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | |
| 3910 | BIO 1211 |
| Selective α4β1 (VLA-4) inhibitor | |
| 5051 | BIO 5192 |
| Highly potent and selective inhibitor of integrin α4β1 | |
| 4776 | BIRT 377 |
| Potent negative allosteric modulator of LFA-1 | |
| 6047 | BOP |
| Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs | |
| 4724 | BTT 3033 |
| Selective inhibitor of integrin α2β1 | |
| 5870 | Cilengitide |
| Potent and selective inhibitor of integrins αvβ3 and αvβ5 | |
| 3202 | Echistatin, α1 isoform |
| Integrin αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor | |
| 6102 | Ep23, 5'-DY647 |
| High affinity fluorescently tagged aptamer for EpCam | |
| 4725 | Eptifibatide |
| Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation | |
| 1263 | GR 144053 trihydrochloride |
| Glycoprotein IIb/IIIa (integrin αIIbβ3) antagonist. Antithrombotic | |
| 2812 | Heparin sodium salt |
| Anticoagulant | |
| 2748 | KF 38789 |
| Selective inhibitor of P-selectin-mediated cell adhesion | |
| 4577 | LDV FITC |
| Fluorescent ligand for α4β1 (VLA-4) | |
| 4921 | Leukadherin 1 |
| Allosteric activator of CD11b/CD18 | |
| 2877 | MNS |
| Glycoprotein IIb/IIIa (αIIbβ3) inhibitor. Also inhibits Src and Syk | |
| 4664 | Obtustatin |
| Potent and selective α1β1 inhibitor | |
| 2710 | OGT 2115 |
| Heparanase inhibitor. Antiangiogenic | |
| 5760 | P-3FAX-Neu5Ac |
| Sialic acid analog; reduces binding of E- and P-selectin | |
| 4744 | P11 |
| Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic | |
| 6394 | Peptide5 |
| Connexin43 mimetic peptide | |
| 4034 | PM 102 |
| Antagonist of heparin (Cat. No. 2812) | |
| 3498 | RGDS peptide |
| Integrin binding sequence; inhibits integrin receptor function | |
| 4227 | RWJ 50271 |
| Inhibitor of LFA-1/ICAM mediated cell adhesion | |
| 4527 | TC-I 15 |
| Potent α2β1 inhibitor; displays antithrombotic activity in vivo | |
| 3900 | TCS 2314 |
| α4β1 (VLA-4) antagonist | |
| 1567 | Thiolutin |
| Antibiotic. Inhibits vitronectin cell adhesion | |
Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.
There are four major families of cell adhesion molecules:
- Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this family include neural cell adhesion molecule (NCAM) and intracellular adhesion molecule (ICAM).
- Selectins - Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).
- Integrins - bind IgSFs and extracellular matrix ligands (e.g. collagen, laminin) and regulate focal adhesion kinase and Src family kinase activity.
- Cadherins - Ca2+-dependent CAMs that are important in cell-cell junctions. Examples include E-cadherin (endothelial), P-cadherin (placental) and N-cadherin (neural).
Literature for Cell Adhesion Molecules
Tocris offers the following scientific literature for Cell Adhesion Molecules to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Adhesion Molecule Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Immunoglobulins | ||||
| NCAM1 | Human | NCAM1 | NM_000615 | Q59FL7 |
| Mouse | Ncam1 | NM_001081445 | P13595 | |
| Rat | Ncam1 | NM_031521 | Q6LDL9 | |
| NCAM2 | Human | NCAM2 | NM_004540 | O15394 |
| Mouse | Ncam2 | NM_010954 | O35136 | |
| Rat | Ncam2 | NM_203409 | Q6RKB2 | |
| ICAM1 | Human | ICAM1 | NM_000201 | P05362 |
| Mouse | Icam1 | NM_010493 | Q62470 | |
| Rat | Icam1 | NM_012967 | Q00238 | |
| ICAM2 | Human | ICAM2 | NM_001099787 | P13598 |
| Mouse | Icam2 | NM_010494 | P35330 | |
| Rat | Icam2 | NM_001007725 | Q6AXM6 | |
| ICAM3 | Human | ICAM3 | NM_002162 | P32942 |
| ICAM4 | Human | ICAM4 | NM_001039132 | Q14773 |
| Mouse | Icam4 | NM_023892 | Q9ERM2 | |
| Rat | Icam4 | XM_233736 | - | |
| ICAM5 | Human | ICAM5 | NM_003259 | Q9UMF0 |
| Mouse | Icam5 | NM_008319 | Q60625 | |
| Rat | Icam5 | XM_233737 | XP_233737 | |
| VCAM1 | Human | VCAM1 | NM_001078 | P19320 |
| Mouse | Vcam1 | NM_011693 | P29533 | |
| Rat | Vcam1 | NM_012889 | P29534 | |
| PECAM1 | Human | PECAM1 | NM_000442 | Q9NQS9 |
| Mouse | Pecam1 | NM_008816 | Q08481 | |
| Rat | Pecam1 | NM_031591 | Q3SWT0 | |
| Selectins | ||||
| E-Selectin | Human | SELE | NM_000450 | P16581 |
| Mouse | Sele | NM_011345 | Q00690 | |
| Rat | Sele | NM_138879 | P98105 | |
| L-Selectin | Human | SELL | NM_000655 | P14151 |
| Mouse | Sell | NM_011346 | P18337 | |
| Rat | Sell | NM_019177 | P30836 | |
| P-Selectin | Human | SELP | NM_003005 | P16109 |
| Mouse | Selp | NM_011347 | Q01102 | |
| Rat | Selp | NM_013114 | Q3MID1 | |
| Integrins | ||||
| α1 | Human | ITGA1 | NM_181501 | P56199 |
| Mouse | Itga1 | NM_001033228 | Q3V3R4 | |
| Rat | Itga1 | NM_030994 | P18614 | |
| α2 | Human | ITGA2 | NM_002203 | P17301 |
| Mouse | Itga2 | NM_008396 | Q62469 | |
| Rat | Itga2 | XM_345156 | Q924S3 | |
| α3 | Human | ITGA3 | NM_005501 | P26006 |
| Mouse | Itga3 | NM_013565 | Q62470 | |
| Rat | Itga3 | NM_001108292 | XP_340885 | |
| α4 | Human | IGTA4 | NM_000885 | P13612 |
| Mouse | Igta4 | NM_010576 | Q00651 | |
| Rat | Igta4 | NM_001107737 | XP_230033 | |
| α5 | Human | ITGA5 | NM_002205 | P08648 |
| Mouse | Itga5 | NM_010577 | P11688 | |
| Rat | Itga5 | NM_001108118 | Q7M074 | |
| α6 | Human | ITGA6 | NM_001079818 | Q53RX7 |
| Mouse | Itga6 | NM_008397 | Q61739 | |
| Rat | Igta6 | XM_215984 | Q924W3 | |
| α7 | Human | ITGA7 | NM_002206 | Q13683 |
| Mouse | Itga7 | NM_008398 | Q61738 | |
| Rat | Itga7 | NM_030842 | Q63258 | |
| α8 | Human | ITGA8 | NM_003638 | P53708 |
| Mouse | Itga8 | NM_001001309 | A2ARA8 | |
| Rat | Itga8 | AF148797 | Q9WUP8 | |
| α9 | Human | ITGA9 | NM_002207 | Q13797 |
| Mouse | Itga9 | NM_133721 | NP_598482 | |
| Rat | Itga9 | XM_001061864 | XP_001061864 | |
| α10 | Human | ITGA10 | NM_003637 | O75578 |
| Mouse | Itga10 | NM_001081053 | NP_001074522 | |
| Rat | Itga10 | NM_001107699 | XP_227469 | |
| α11 | Human | ITGA11 | NM_012211 | Q9UKX5 |
| Mouse | Itga11 | NM_176922 | P61622 | |
| Rat | Itga11 | NM_001108156 | XP_236320 | |
| αD | Human | ITGAD | NM_005353 | Q13349 |
| Mouse | Itgad | NM_001029872 | Q3V0T4 | |
| Rat | Itgad | NM_031691 | Q9QYE7 | |
| αE | Human | ITGAE | NM_002208 | P38570 |
| Mouse | Itgae | NM_008399 | Q60677 | |
| Rat | Itgae | NM_031768 | O88340 | |
| αL | Human | ITGAL | NM_002209 | P20701 |
| Mouse | Itgal | NM_008400 | P24063 | |
| Rat | Itgal | NM_001033998 | Q3T1L6 | |
| αM | Human | ITGAM | NM_000632 | P11215 |
| Mouse | Itgam | NM_001082960 | P05555 | |
| Rat | Igtam | NM_012711 | Q9JI30 | |
| αV | Human | ITGAV | NM_002210 | P06756 |
| Mouse | Itgav | NM_008402 | P43406 | |
| Rat | Itgav | NM_001106549 | XP_230950 | |
| αX | Human | ITGAX | NM_000887 | P20702 |
| Mouse | Itgax | NM_021334 | Q9QXH4 | |
| Rat | Itgax | XM_574569 | XP_574569 | |
| β1 | Human | ITGB1 | NM_002211 | Q14622 |
| Mouse | Itgb1 | NM_010578 | P09055 | |
| Rat | Itgb1 | NM_017022 | P49134 | |
| β2 | Human | ITGB2 | NM_000211 | P05107 |
| Mouse | Itgb2 | NM_008404 | P11835 | |
| Rat | Itgb2 | NM_001037780 | Q4KLK5 | |
| β3 | Human | ITGB3 | NM_000212 | P05106 |
| Mouse | Itgb3 | NM_016780 | O54890 | |
| Rat | Itgb3 | NM_153720 | Q8R2H2 | |
| β4 | Human | ITGB4 | NM_001005731 | P16144 |
| Mouse | Itgb4 | NM_001005608 | NP_001005608 | |
| Rat | Itgb4 | NM_013180 | Q64632 | |
| β5 | Human | ITGB5 | NM_002213 | P18084 |
| Mouse | Itgb5 | NM_010580 | O70309 | |
| Rat | Itgb5 | NM_147139.2 | Q8VIM7 | |
| β6 | Human | ITGB6 | NM_000888 | P18564 |
| Mouse | Itgb6 | NM_021359 | Q9Z0T9 | |
| Rat | Itgb6 | NM_001004263 | Q6AYF4 | |
| β7 | Human | ITGB7 | NM_000889 | P26010 |
| Mouse | Itgb7 | NM_013566 | P26011 | |
| Rat | Itgb7 | XM_343336 | Q4G029 | |
| β8 | Human | ITGB8 | NM_002214 | P26012 |
| Mouse | Itgb8 | NM_177290 | NP_796264 | |
| Rat | Itgb8 | NM_001108726 | XP_343127 | |
| Cadherins | ||||
|
E-cadherin (Cadherin 1) |
Human | CDH1 | NM_004360 | P12830 |
| Mouse | Cdh1 | NM_009864 | P09803 | |
| Rat | Cdh1 | NM_031334 | Q9R0T4 | |
|
N-cadherin (Cadherin 2) |
Human | CDH2 | NM_001792 | P19022 |
| Mouse | Cdh2 | NM_007664 | P15116 | |
| Rat | Cdh2 | NM_031333 | Q9Z1Y3 | |
|
P-cadherin (Cadherin 3) |
Human | CDH3 | NM_001793 | P22223 |
| Mouse | Cdh3 | NM_001037809 | P10287 | |
| Rat | Cdh3 | XM_226426 | Q9JIV6 | |
|
R-cadherin (Cadherin 4) |
Human | CDH4 | NM_001794 | P55283 |
| Mouse | Cdh4 | NM_009867 | P39038 | |
| Rat | Cdh4 | XM_230955 | XP_230955 | |
|
VE-cadherin (Cadherin 5) |
Human | CDH5 | NM_001795 | P33151 |
| Mouse | Cdh5 | NM_009868 | P55284 | |
| Rat | Cdh5 | NM_001107407 | XP_226213 | |
|
K-cadherin (Cadherin 6) |
Human | CDH6 | NM_004932 | P55285 |
| Mouse | Cdh6 | NM_007666 | P97326 | |
| Rat | Cdh6 | NM_012927 | P55280 | |
| Cadherin 7 | Human | CDH7 | NM_033646 | Q9ULB5 |
| Mouse | Cdh7 | NM_172853 | Q8BM92 | |
| Rat | Cdh7 | NM_001012737 | Q5DWV2 | |
| Cadherin 8 | Human | CDH8 | NM_001796 | P55286 |
| Mouse | Cdh8 | NM_001039154 | P97291 | |
| Rat | Cdh8 | NM_053393 | O54800 | |
|
T1-cadherin (Cadherin 9) |
Human | CDH9 | NM_016279 | Q9ULB4 |
| Mouse | Cdh9 | NM_009869 | P70407 | |
| Rat | Cdh9 | XM_226861 | XP_226861 | |
|
T2-cadherin (Cadherin 10) |
Human | CDH10 | NM_006727 | Q9Y6N8 |
| Mouse | Cdh10 | NM_009865 | P70408 | |
| Rat | Cdh10 | XM_342202 | Q8R5H2 | |
|
OB-cadherin (Cadherin 11) |
Human | CDH11 | NM_033664 | P55287 |
| Mouse | Cdh11 | NM_009866 | P55288 | |
| Rat | Cdh11 | XM_341639 | Q63760 | |
|
N-cadherin 2 (Cadherin 12) |
Human | CDH12 | NM_004061 | P55289 |
| Mouse | Cdh12 | NM_001008420 | Q5RJH3 | |
| Rat | Cdh12 | XM_229369 | XP_229369 | |
|
H-cadherin (Cadherin 13) |
Human | CDH13 | NM_001257 | P55290 |
| Mouse | Cdh13 | NM_019707 | Q9WTR5 | |
| Rat | Cdh13 | NM_138889 | Q8R490 | |
|
M-cadherin (Cadherin 15) |
Human | CDH15 | NM_004933 | P55291 |
| Mouse | Cdh15 | NM_007662 | P33146 | |
| Rat | Cdh15 | NM_207613 | Q75NI5 | |
|
KSP-cadherin (Cadherin 16) |
Human | CDH16 | NM_004062 | O75309 |
| Mouse | Cdh16 | NM_007663 | O88338 | |
| Rat | Cdh16 | NM_001012055 | Q66H67 | |
|
LI-cadherin (Cadherin 17) |
Human | CDH17 | NM_004063 | Q12864 |
| Mouse | Cdh17 | NM_019753 | Q9R100 | |
| Rat | Cdh17 | NM_053977 | P55281 | |
| Cadherin 18 | Human | CDH18 | NM_004934 | Q13634 |
| Mouse | Cdh18 | NM_001081299 | NP_001074768 | |
| Rat | Cdh18 | NM_001107656 | XP_226899 | |
| Cadherin 19 | Human | CDH19 | NM_021153 | Q9H159 |
| Mouse | Cdh19 | NM_001081386 | NP_001074855 | |
| Rat | Cdh19 | NM_001009448 | Q5NUI3 | |
| Cadherin 20 | Human | CDH20 | NM_031891 | Q9HBT6 |
| Mouse | Cdh20 | NM_011800 | Q9Z0M3 | |
| Rat | Cdh20 | NM_001012748 | Q5DWV1 | |
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