You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued ProductSildenafil citrate (Cat. No. 3784) has been withdrawn from sale for commercial reasons.
Biological Activity for Sildenafil citrate
Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Sildenafil citrate
Technical Data for Sildenafil citrate
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sildenafil citrate
References for Sildenafil citrate
References are publications that support the biological activity of the product.
Ballard et al (1998) Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164 PMID: 9598563
Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds. Mol.Pharmacol. 56 124 PMID: 10385692
Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689 PMID: 16883306
Smith-Berdan et al (2019) Viagra enables efficient, single-day hematopoietic stem cell mobilization. Stem Cell Reports. PMID: 31607567
View Related Products by Product Action
Keywords: Sildenafil citrate, Sildenafil citrate supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, Pfizer, HSC, hematopoietic, haematopoietic, stem, cells, mobilization, COVID-19, pulmonary, edema, Phosphodiesterases, Stem, Cell, Proliferation, 3784, Tocris Bioscience
1 Citation for Sildenafil citrate
Citations are publications that use Tocris products. Selected citations for Sildenafil citrate include:
Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Development 8 e72155 PMID: 24015214
Reviews for Sildenafil citrate
There are currently no reviews for this product. Be the first to review Sildenafil citrate and earn rewards!
Have you used Sildenafil citrate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.