Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 666.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.5 mL||7.5 mL||15 mL|
|5 mM||0.3 mL||1.5 mL||3 mL|
|10 mM||0.15 mL||0.75 mL||1.5 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
References are publications that support the products' biological activity.
Ballard et al (1998) Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164 PMID: 9598563
Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol.Pharmacol. 56 124 PMID: 10385692
Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689 PMID: 16883306
If you know of a relevant reference for Sildenafil citrate, please let us know.
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Keywords: Sildenafil citrate, supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, Pfizer, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
1 Citation for Sildenafil citrate
Citations are publications that use Tocris products. Selected citations for Sildenafil citrate include:
Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Development 8 e72155 PMID: 24015214
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