Sildenafil citrate

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Cat.No. 3784 - Sildenafil citrate | C22H30N6O4S.C6H8O7 | CAS No. 171599-83-0
Description: Orally active, potent PDE5 inhibitor
Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Sildenafil citrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 666.7
Formula C22H30N6O4S.C6H8O7
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 171599-83-0
PubChem ID 62853
InChI Key DEIYFTQMQPDXOT-UHFFFAOYSA-N
Smiles O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 666.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.5 mL 7.5 mL 15 mL
5 mM 0.3 mL 1.5 mL 3 mL
10 mM 0.15 mL 0.75 mL 1.5 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ballard et al (1998) Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164 PMID: 9598563

Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol.Pharmacol. 56 124 PMID: 10385692

Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689 PMID: 16883306


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Keywords: Sildenafil citrate, supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, Pfizer, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

1 Citation for Sildenafil citrate

Citations are publications that use Tocris products. Selected citations for Sildenafil citrate include:

Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Development 8 e72155 PMID: 24015214


Do you know of a great paper that uses Sildenafil citrate from Tocris? If so please let us know.

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