Pyrintegrin

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Cat.No. 4978 - Pyrintegrin | C23H25N5O3S | CAS No. 1228445-38-2
Description: Enhances survival of human ESCs following enzymatic dissociation
Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.

Compound Libraries

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Technical Data

M. Wt 451.54
Formula C23H25N5O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1228445-38-2
PubChem ID 46223724
InChI Key QRJTZIJWDLJKQO-UHFFFAOYSA-N
Smiles OC(C=C3)=CC2=C3N(CCC2)C1=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 451.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Xu et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci.USA 107 8129 PMID: 20406903

Lee et al (2015) A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J.Am.Soc.Nephrol 26 2741 PMID: 25858967


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Keywords: Pyrintegrin, Pyrintegrin supplier, human, embryonic, stem, cells, hESCs, survival, culture, podocytes, renal, kidney, protective, Stem, Cell, Proliferation, 4978, Tocris Bioscience

Citations for Pyrintegrin

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Literature in this Area

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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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