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Biological Activity for Thiazovivin
Thiazovivin is a ROCK inhibitor. Enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Improves the survival of human embryonic stem cells (hESCs) upon trypsinization.
Technical Data for Thiazovivin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Thiazovivin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Thiazovivin
The following data is based on the product molecular weight 311.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.21 mL||16.06 mL||32.12 mL|
|5 mM||0.64 mL||3.21 mL||6.42 mL|
|10 mM||0.32 mL||1.61 mL||3.21 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References for Thiazovivin
References are publications that support the biological activity of the product.
Lin et al (2009) A chemical platform for improved induction of human iPSCs. Nat.Methods. 6 805 PMID: 19838168
Xu et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci. USA 107 8129 PMID: 20406903
If you know of a relevant reference for Thiazovivin, please let us know.
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Keywords: Thiazovivin, Thiazovivin supplier, stem, cells, reprogramming, dedifferentiation, enhances, enhancers, induces, induced, pluripotent, ipscs, escs, Stem, Cell, Reprogramming, Rho-kinases, Proliferation, 3845, Tocris Bioscience
5 Citations for Thiazovivin
Citations are publications that use Tocris products. Selected citations for Thiazovivin include:
Tumelty et al (2018) Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem 293 3039 PMID: 29317497
Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410
Brown (2017) Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates. Cell Rep 21 301 PMID: 29020617
Sevilla et al (2018) Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions. Stem Cell Res 29 197 PMID: 29730569
Xu et al (2016) Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells. Proc Natl Acad Sci U S A 113 E6382 PMID: 27698112
Do you know of a great paper that uses Thiazovivin from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.