Thiazovivin

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Cat.No. 3845 - Thiazovivin | C15H13N5OS | CAS No. 1226056-71-8
Description: Improves the efficiency of fibroblast reprogramming and induction of iPSCs
Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Greatly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Improves the survival of human embryonic stem cells (hESCs) upon trypsinization.

Compound Libraries

Thiazovivin is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 311.36
Formula C15H13N5OS
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1226056-71-8
PubChem ID 46209426
InChI Key DOBKQCZBPPCLEG-UHFFFAOYSA-N
Smiles O=C(NCC3=CC=CC=C3)C1=CSC(NC2=CC=NC=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 311.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.06 mL 32.12 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.61 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lin et al (2009) A chemical platform for improved induction of human iPSCs. Nat.Methods. 6 805 PMID: 19838168

Xu et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci. USA 107 8129 PMID:


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Keywords: stem cells reprogramming dedifferentiation enhances enhancers induces induced pluripotent stem cells ipscs escs Reprogramming

Citations for Thiazovivin

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Literature in this Area

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for Thiazovivin

Protocols

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