Thiazovivin

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Cat.No. 3845 - Thiazovivin | C15H13N5OS | CAS No. 1226056-71-8
Description: ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs
Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (6)

Biological Activity

ROCK inhibitor. Enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Improves the survival of human embryonic stem cells (hESCs) upon trypsinization.

Compound Libraries

Thiazovivin is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 311.36
Formula C15H13N5OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1226056-71-8
PubChem ID 46209426
InChI Key DOBKQCZBPPCLEG-UHFFFAOYSA-N
Smiles O=C(NCC3=CC=CC=C3)C1=CSC(NC2=CC=NC=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 311.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.06 mL 32.12 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.61 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lin et al (2009) A chemical platform for improved induction of human iPSCs. Nat.Methods. 6 805 PMID: 19838168

Xu et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci. USA 107 8129 PMID: 20406903


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Keywords: Thiazovivin, Thiazovivin supplier, stem, cells, reprogramming, dedifferentiation, enhances, enhancers, induces, induced, pluripotent, ipscs, escs, Stem, Cell, Reprogramming, Rho-kinases, Proliferation, 3845, Tocris Bioscience

4 Citations for Thiazovivin

Citations are publications that use Tocris products. Selected citations for Thiazovivin include:

Tumelty et al (2018) Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem 293 3039 PMID: 29317497

Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410

Brown (2017) Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates. Cell Rep 21 301 PMID: 29020617

Xu et al (2016) Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells. Proc Natl Acad Sci U S A 113 E6382 PMID: 27698112


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Literature in this Area

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