Integrins

Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Products
Background
Literature
Gene Data

Modulators

Cat No Product Name / Activity
4776 BIRT 377
Potent negative allosteric modulator of LFA-1

Inhibitors

Cat No Product Name / Activity
2524 A 205804
Selective inhibitor of E-selectin and ICAM-1 expression
4228 A 286982
Potent inhibitor of the LFA-1/ICAM-1 interaction
6058 ATN 161
α5β1 integrin receptor antagonist
3910 BIO 1211
Selective α4β1 (VLA-4) inhibitor
5051 BIO 5192
Highly potent and selective inhibitor of integrin α4β1
6047 BOP
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
4724 BTT 3033
Selective inhibitor of integrin α2β1
5870 Cilengitide
Potent and selective inhibitor of integrins αvβ3 and αvβ5
3202 Echistatin, α1 isoform
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
4725 Eptifibatide
Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation
1263 GR 144053 trihydrochloride
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
2877 MNS
Glycoprotein IIb/IIIa (αIIbβ3) inhibitor. Also inhibits Src and Syk
4664 Obtustatin
Potent and selective α1β1 inhibitor
4744 P11
Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
6048 R-BC154
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
3498 RGDS peptide
Integrin binding sequence; inhibits integrin receptor function
4527 TC-I 15
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
3900 TCS 2314
α4β1 (VLA-4) antagonist

Activators

Cat No Product Name / Activity
4921 Leukadherin 1
Allosteric activator of CD11b/CD18

Other

Cat No Product Name / Activity
4577 LDV FITC
Fluorescent ligand for α4β1 (VLA-4)
4227 RWJ 50271
Inhibitor of LFA-1/ICAM mediated cell adhesion

Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Integrins 'integrate' the extracellular environment with the cell interior by binding both the extracellular matrix (ECM) and the cytoskeleton. They are critical for cell attachment to the ECM, which is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and α-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis.

Glycoprotein II/IIIb (αIIbβ3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Literature for Integrins

Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Integrin Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α1 Human ITGA1 NM_181501 P56199
Mouse Itga1 NM_001033228 Q3V3R4
Rat Itga1 NM_030994 P18614
α2 Human ITGA2 NM_002203 P17301
Mouse Itga2 NM_008396 Q62469
Rat Itga2 XM_345156 Q924S3
α3 Human ITGA3 NM_005501 P26006
Mouse Itga3 NM_013565 Q62470
Rat Itga3 NM_001108292 XP_340885
α4 Human IGTA4 NM_000885 P13612
Mouse Igta4 NM_010576 Q00651
Rat Igta4 NM_001107737 XP_230033
α5 Human ITGA5 NM_002205 P08648
Mouse Itga5 NM_010577 P11688
Rat Itga5 NM_001108118 Q7M074
α6 Human ITGA6 NM_001079818 Q53RX7
Mouse Itga6 NM_008397 Q61739
Rat Igta6 XM_215984 Q924W3
α7 Human ITGA7 NM_002206 Q13683
Mouse Itga7 NM_008398 Q61738
Rat Itga7 NM_030842 Q63258
α8 Human ITGA8 NM_003638 P53708
Mouse Itga8 NM_001001309 A2ARA8
Rat Itga8 AF148797 Q9WUP8
α9 Human ITGA9 NM_002207 Q13797
Mouse Itga9 NM_133721 NP_598482
Rat Itga9 XM_001061864 XP_001061864
α10 Human ITGA10 NM_003637 O75578
Mouse Itga10 NM_001081053 NP_001074522
Rat Itga10 NM_001107699 XP_227469
α11 Human ITGA11 NM_012211 Q9UKX5
Mouse Itga11 NM_176922 P61622
Rat Itga11 NM_001108156 XP_236320
αD Human ITGAD NM_005353 Q13349
Mouse Itgad NM_001029872 Q3V0T4
Rat Itgad NM_031691 Q9QYE7
αE Human ITGAE NM_002208 P38570
Mouse Itgae NM_008399 Q60677
Rat Itgae NM_031768 O88340
αL Human ITGAL NM_002209 P20701
Mouse Itgal NM_008400 P24063
Rat Itgal NM_001033998 Q3T1L6
αM Human ITGAM NM_000632 P11215
Mouse Itgam NM_001082960 P05555
Rat Igtam NM_012711 Q9JI30
αV Human ITGAV NM_002210 P06756
Mouse Itgav NM_008402 P43406
Rat Itgav NM_001106549 XP_230950
αX Human ITGAX NM_000887 P20702
Mouse Itgax NM_021334 Q9QXH4
Rat Itgax XM_574569 XP_574569
β1 Human ITGB1 NM_002211 Q14622
Mouse Itgb1 NM_010578 P09055
Rat Itgb1 NM_017022 P49134
β2 Human ITGB2 NM_000211 P05107
Mouse Itgb2 NM_008404 P11835
Rat Itgb2 NM_001037780 Q4KLK5
β3 Human ITGB3 NM_000212 P05106
Mouse Itgb3 NM_016780 O54890
Rat Itgb3 NM_153720 Q8R2H2
β4 Human ITGB4 NM_001005731 P16144
Mouse Itgb4 NM_001005608 NP_001005608
Rat Itgb4 NM_013180 Q64632
β5 Human ITGB5 NM_002213 P18084
Mouse Itgb5 NM_010580 O70309
Rat Itgb5 NM_147139.2 Q8VIM7
β6 Human ITGB6 NM_000888 P18564
Mouse Itgb6 NM_021359 Q9Z0T9
Rat Itgb6 NM_001004263 Q6AYF4
β7 Human ITGB7 NM_000889 P26010
Mouse Itgb7 NM_013566 P26011
Rat Itgb7 XM_343336 Q4G029
β8 Human ITGB8 NM_002214 P26012
Mouse Itgb8 NM_177290 NP_796264
Rat Itgb8 NM_001108726 XP_343127