16,16-Dimethyl Prostaglandin E2

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Description: Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity: ≥95% (HPLC)
Citations (3)

Biological Activity for 16,16-Dimethyl Prostaglandin E2

16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data for 16,16-Dimethyl Prostaglandin E2

M. Wt 380.52
Formula C22H36O5
Storage Store at -80°C
Purity ≥95% (HPLC)
CAS Number 39746-25-3
PubChem ID 5283066
Smiles O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 16,16-Dimethyl Prostaglandin E2

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Product Datasheets for 16,16-Dimethyl Prostaglandin E2

Certificate of Analysis / Product Datasheet
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References for 16,16-Dimethyl Prostaglandin E2

References are publications that support the biological activity of the product.

Lord et al (2007) Prostaglandin E2: making more of your marrow. Cell Cycle. 6 3054 PMID: 18075310

Goessling et al (2009) Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136 1136 PMID: 19303855

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007 PMID: 17581586

Heffner et al (2018) Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther. 26 320 PMID: 29102562

If you know of a relevant reference for 16,16-Dimethyl Prostaglandin E2, please let us know.

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Keywords: 16,16-Dimethyl Prostaglandin E2, 16,16-Dimethyl Prostaglandin E2 supplier, synthetic, prostaglandin, prostanoid, receptors, agonists, hematopoietic, haematopoietic, stem, cells, HSCs, PGE2, organoids, HSC, Prostanoid, Receptors, Stem, Cell, Signaling, Proliferation, Viral, Transduction, Enhancers, Hematopoietic, Cells, 4027, Tocris Bioscience

3 Citations for 16,16-Dimethyl Prostaglandin E2

Citations are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:

Helen M et al (2017) Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength. Proc Natl Acad Sci U S A 114 6675-6684 PMID: 28607093

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Oncotarget 19 210 PMID: 25266063

Yoko et al (2021) COX2 regulates senescence secretome composition and senescence surveillance through PGE2. Cell Rep 34 108860 PMID: 33730589

Do you know of a great paper that uses 16,16-Dimethyl Prostaglandin E2 from Tocris? Please let us know.

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