16,16-Dimethyl Prostaglandin E2

Pricing Availability   Qty
Description: Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity for 16,16-Dimethyl Prostaglandin E2

16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data for 16,16-Dimethyl Prostaglandin E2

M. Wt 380.52
Formula C22H36O5
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 39746-25-3
PubChem ID 5283066
InChI Key QAOBBBBDJSWHMU-WMBBNPMCSA-N
Smiles O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 16,16-Dimethyl Prostaglandin E2

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Product Datasheets for 16,16-Dimethyl Prostaglandin E2

Certificate of Analysis / Product Datasheet
Select another batch:

References for 16,16-Dimethyl Prostaglandin E2

References are publications that support the biological activity of the product.

Lord et al (2007) Prostaglandin E2: making more of your marrow. Cell Cycle. 6 3054 PMID: 18075310

Goessling et al (2009) Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136 1136 PMID: 19303855

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007 PMID: 17581586

Heffner et al (2018) Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther. 26 320 PMID: 29102562


If you know of a relevant reference for 16,16-Dimethyl Prostaglandin E2, please let us know.

View Related Products by Product Action

View all Prostanoid Receptor Agonists

Keywords: 16,16-Dimethyl Prostaglandin E2, 16,16-Dimethyl Prostaglandin E2 supplier, synthetic, prostaglandin, prostanoid, receptors, agonists, hematopoietic, haematopoietic, stem, cells, HSCs, PGE2, organoids, HSC, Prostanoid, Receptors, Stem, Cell, Signaling, Proliferation, Viral, Transduction, Enhancers, Hematopoietic, Cells, 4027, Tocris Bioscience

1 Citation for 16,16-Dimethyl Prostaglandin E2

Citations are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Oncotarget 19 210 PMID: 25266063


Do you know of a great paper that uses 16,16-Dimethyl Prostaglandin E2 from Tocris? Please let us know.

Reviews for 16,16-Dimethyl Prostaglandin E2

There are currently no reviews for this product. Be the first to review 16,16-Dimethyl Prostaglandin E2 and earn rewards!

Have you used 16,16-Dimethyl Prostaglandin E2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pain Poster

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.