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16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)|
References are publications that support the biological activity of the product.
Lord et al (2007) Prostaglandin E2: making more of your marrow. Cell Cycle. 6 3054 PMID: 18075310
Goessling et al (2009) Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136 1136 PMID: 19303855
North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007 PMID: 17581586
Heffner et al (2018) Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther. 26 320 PMID: 29102562
If you know of a relevant reference for 16,16-Dimethyl Prostaglandin E2, please let us know.
Keywords: 16,16-Dimethyl Prostaglandin E2, 16,16-Dimethyl Prostaglandin E2 supplier, synthetic, prostaglandin, prostanoid, receptors, agonists, hematopoietic, haematopoietic, stem, cells, HSCs, PGE2, organoids, HSC, Prostanoid, Receptors, Stem, Cell, Signaling, Proliferation, Viral, Transduction, Enhancers, Hematopoietic, Cells, 4027, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:
Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Oncotarget 19 210 PMID: 25266063
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.