16,16-Dimethyl Prostaglandin E2

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Cat.No. 4027 - 16,16-Dimethyl Prostaglandin E2 | C22H36O5 | CAS No. 39746-25-3
Description: Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data

M. Wt 380.52
Formula C22H36O5
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 39746-25-3
PubChem ID 5283066
InChI Key QAOBBBBDJSWHMU-WMBBNPMCSA-N
Smiles O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 380.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lord et al (2007) Prostaglandin E2: making more of your marrow. Cell Cycle 6 3054 PMID: 18075310

Goessling et al (2009) Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136 1136 PMID: 19303855

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. 447 1007 PMID: 17581586


If you know of a relevant reference for 16,16-Dimethyl Prostaglandin E2, please let us know.

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Keywords: synthetic prostaglandin prostanoid receptors agonists hematopoietic haematopoietic stem cells HSCs PGE2 organoids Prostanoid Receptors

1 Citation for 16,16-Dimethyl Prostaglandin E2

Citations are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Oncotarget 19 210 PMID: 25266063


Do you know of a great paper that uses 16,16-Dimethyl Prostaglandin E2 from Tocris? If so please let us know.

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Pathways for 16,16-Dimethyl Prostaglandin E2

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