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StemRegenin 1 New
Biological Activity for StemRegenin 1
StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
Technical Data for StemRegenin 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for StemRegenin 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for StemRegenin 1
The following data is based on the product molecular weight 429.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.33 mL||11.64 mL||23.28 mL|
|5 mM||0.47 mL||2.33 mL||4.66 mL|
|10 mM||0.23 mL||1.16 mL||2.33 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References for StemRegenin 1
References are publications that support the biological activity of the product.
Jackson et al (2017) Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 21 124 PMID: 28445828
Genovese et al (2014) Targeted genome editing in human repopulating haematopoietic stem cells. Nature 510 235 PMID: 24870228
Boitano et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329 1345 PMID: 20688981
Koide et al (2016) Aryl hydrocarbon receptor antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4. Anticancer Res. 36 3635 PMID: 27354634
If you know of a relevant reference for StemRegenin 1, please let us know.
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Keywords: StemRegenin 1, StemRegenin 1 supplier, SR1, aryl, hydrocarbon, receptors, antagonists, antagonizes, antagonism, AHR, hematopoietic, haematopoietic, stem, cells, HSCs, CD34, expansion, engraftment, Aryl, Hydrocarbon, Receptors, Stem, Cell, Proliferation, 7086, Tocris Bioscience
Citations for StemRegenin 1
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Literature in this Area
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