Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 429.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.33 mL||11.64 mL||23.28 mL|
|5 mM||0.47 mL||2.33 mL||4.66 mL|
|10 mM||0.23 mL||1.16 mL||2.33 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
Jackson et al (2017) Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 21 124 PMID: 28445828
Genovese et al (2014) Targeted genome editing in human repopulating haematopoietic stem cells. Nature 510 235 PMID: 24870228
Boitano et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329 1345 PMID: 20688981
Koide et al (2016) Aryl hydrocarbon receptor antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4. Anticancer Res. 36 3635 PMID: 27354634
If you know of a relevant reference for StemRegenin 1, please let us know.
Keywords: StemRegenin 1, StemRegenin 1 supplier, SR1, aryl, hydrocarbon, receptors, antagonists, antagonizes, antagonism, AHR, hematopoietic, haematopoietic, stem, cells, HSCs, CD34, expansion, engraftment, HSC, Aryl, Hydrocarbon, Receptors, Stem, Cell, Proliferation, Hematopoietic, Cells, 7086, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for StemRegenin 1. Do you know of a great paper that uses StemRegenin 1 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review StemRegenin 1 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.