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RGD peptide is a potent integrin inhibitor (IC50 values are 89, 335 and 440 nM for αvβ3, α5β1 and αvβ5, respectively). RGD is the minimal recognition sequence for integrin binding found in many extracellular matrix (ECM) and serum proteins. RGD peptide is used for directing association of various cell types with diverse biomaterials. The functionality of RGD peptide is usually maintained throughout the processing and sterilization steps required for biomaterials synthesis. RGD peptide can be incorporated into hyaluronic acid hydrogel for human mesenchymal stem cells (hMSCs) delivery. RGD peptide significantly increases hMSC spreading and protein secretion under standard or ischemic culture conditions. RGD peptide can also be incorporated into alginate bioink for 3D bioprinting of MSCs onto cartilage templates for bone organogenesis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 10 mg/ml in water|
References are publications that support the biological activity of the product.
Bellis (2011) Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials 32 4205 PMID: 21515168
Ruoslahti et al (1987) New perspectives in cell adhesion: RGD and integrins. Science 238 491 PMID: 2821619
Kapp et al (2017) A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci.Rep. 7 39805 PMID: 28074920
Gallagher et al (2020) Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions. Acta.Biomater. 107 78 PMID: 32145393
Daly et al (2016) 3D bioprinting of developmentally inspired templates for whole bone organ engineering. Adv.Healthc.Mater. 5 2353 PMID: 27281607
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