Pioglitazone hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4124 - Pioglitazone hydrochloride | C19H20N2O3S.HCl | CAS No. 112529-15-4
Description: Selective PPARγ agonist; antidiabetic agent
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.

Compound Libraries

Pioglitazone hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 392.9
Formula C19H20N2O3S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 112529-15-4
PubChem ID 60560
InChI Key GHUUBYQTCDQWRA-UHFFFAOYSA-N
Smiles O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.82 25

Preparing Stock Solutions

The following data is based on the product molecular weight 392.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.73 mL 25.45 mL
5 mM 0.51 mL 2.55 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem.Biophys.Res.Commun. 278 704 PMID: 11095972

Smith (2001) Pioglitazone: mechanism of action. Int.J.Clin.Pract.Suppl. 121 13 PMID: 11594239

Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J.Med.Chem. 45 1518 PMID: 11906293


If you know of a relevant reference for Pioglitazone hydrochloride, please let us know.

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View all PPARγ Agonists

Keywords: PPARg PPARgamma PPARγ peroxisome proliferator activated receptors nuclear agonists antidiabetic agents PPARgamma Receptors

3 Citations for Pioglitazone hydrochloride

Citations are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:

Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481 PMID: 25759824

Thakran et al (2015) Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177 PMID: 25525174

Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283 PMID: 24812009


Do you know of a great paper that uses Pioglitazone hydrochloride from Tocris? If so please let us know.

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Pathways for Pioglitazone hydrochloride

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