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Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat.No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 392.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.18 mL||50.9 mL||101.81 mL|
|1.25 mM||2.04 mL||10.18 mL||20.36 mL|
|2.5 mM||1.02 mL||5.09 mL||10.18 mL|
|12.5 mM||0.2 mL||1.02 mL||2.04 mL|
References are publications that support the biological activity of the product.
Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907
Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglit. Biochem.Biophys.Res.Commun. 278 704 PMID: 11095972
Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as Ins sensitizers with antidiabetic activities. J.Med.Chem. 45 1518 PMID: 11906293
Kajabadi et al (2015) The synergistic enhancement of cloning efficiency in individualized human pluripotent stem cells by peroxisome proliferative-activated receptor-γ (PPARγ) activation and Rho-associated kinase (ROCK) inhibition. J.Biol.Chem. 290 26303 PMID: 26336103
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Keywords: Pioglitazone hydrochloride, Pioglitazone hydrochloride supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, stem, cell, dissociation, cloning, effciency, Receptors, Stem, Cell, Proliferation, 4124, Tocris Bioscience
5 Citations for Pioglitazone hydrochloride
Citations are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:
Merkulova et al (2019) Ponatinib treatment promotes arterial thrombosis and hyperactive platelets. Blood Adv 3 2312 PMID: 31383636
Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481 PMID: 25759824
Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283 PMID: 24812009
Thakran et al (2015) Pioglit restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177 PMID: 25525174
Helmy et al (2015) Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID: 26536032
Do you know of a great paper that uses Pioglitazone hydrochloride from Tocris? Please let us know.
Reviews for Pioglitazone hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Pioglitazone hydrochloride promotes macrophage M2 polarization. To achieve this M0 macrophages BMDM (bone marrow-derived macrophages) stimulated with pioglitazone (5 µm) for 24 h.
Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.