Pioglitazone hydrochloride

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Cat.No. 4124 - Pioglitazone hydrochloride | C19H20N2O3S.HCl | CAS No. 112529-15-4
Description: Selective PPARγ agonist; antidiabetic agent
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews (1)
Literature (4)

Biological Activity

Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat.No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.

Compound Libraries

Pioglitazone hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 392.9
Formula C19H20N2O3S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 112529-15-4
PubChem ID 60560
InChI Key GHUUBYQTCDQWRA-UHFFFAOYSA-N
Smiles O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.82 25

Preparing Stock Solutions

The following data is based on the product molecular weight 392.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.18 mL 50.9 mL 101.81 mL
1.25 mM 2.04 mL 10.18 mL 20.36 mL
2.5 mM 1.02 mL 5.09 mL 10.18 mL
12.5 mM 0.2 mL 1.02 mL 2.04 mL

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Keywords: Pioglitazone hydrochloride, Pioglitazone hydrochloride supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, stem, cell, dissociation, cloning, effciency, Receptors, Stem, Cell, Proliferation, 4124, Tocris Bioscience

5 Citations for Pioglitazone hydrochloride

Citations are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:

Merkulova et al (2019) Ponatinib treatment promotes arterial thrombosis and hyperactive platelets. Blood Adv 3 2312 PMID: 31383636

Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481 PMID: 25759824

Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283 PMID: 24812009

Thakran et al (2015) Pioglit restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177 PMID: 25525174


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Reviews for Pioglitazone hydrochloride

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Pioglitazone hydrochloride promotes macrophage M2 polarization..
By GAJANAN KATKAR on 12/07/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Bone marrow derived macrophage

Pioglitazone hydrochloride promotes macrophage M2 polarization. To achieve this M0 macrophages BMDM (bone marrow-derived macrophages) stimulated with pioglitazone (5 µm) for 24 h.


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