Pricing Availability   Qty
Description: Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
Chemical Name: N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
Purity: ≥98% (HPLC)

Biological Activity for CDK8/19i

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

Compound Libraries for CDK8/19i

CDK8/19i is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CDK8/19i

M. Wt 253.3
Formula C14H15N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 923596-52-5
PubChem ID 68488430
Smiles CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CDK8/19i

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.33 100
ethanol 25.33 100

Preparing Stock Solutions for CDK8/19i

The following data is based on the product molecular weight 253.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.48 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CDK8/19i

References are publications that support the biological activity of the product.

Lynch et al (2020) Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat.Cell.Bio. 22 1223 PMID: 32989249

If you know of a relevant reference for CDK8/19i, please let us know.

View Related Products by Product Action

View all Transcriptional CDK Inhibitors

Keywords: CDK8/19i, CDK8/19i supplier, cyclin, dependent, kinases, inhibitors, inhibits, CDK8, CDK19, stem, cells, pluripotency, pluripotent, maintenance, self-renewal, potent, selective, Stem, Cell, Proliferation, Transcriptional, CDKs, 7372, Tocris Bioscience

Citations for CDK8/19i

Citations are publications that use Tocris products.

Currently there are no citations for CDK8/19i. Do you know of a great paper that uses CDK8/19i from Tocris? Please let us know.

Reviews for CDK8/19i

There are currently no reviews for this product. Be the first to review CDK8/19i and earn rewards!

Have you used CDK8/19i?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review