CDK8/19i

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Cat.No. 7372 - CDK8/19i | C14H15N5 | CAS No. 923596-52-5
Description: Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
Chemical Name: N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

Technical Data

M. Wt 253.3
Formula C14H15N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 923596-52-5
PubChem ID 68488430
InChI Key XTMROGQLIVGYKF-UHFFFAOYSA-N
Smiles CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.33 100
ethanol 25.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 253.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.48 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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References

References are publications that support the biological activity of the product.

Lynch et al (2020) Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat.Cell.Bio. 22 1223 PMID: 32989249


If you know of a relevant reference for CDK8/19i, please let us know.

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View all Cyclin-Dependent Protein Kinase Inhibitors

Keywords: CDK8/19i, CDK8/19i supplier, cyclin, dependent, kinases, inhibitors, inhibits, CDK8, CDK19, stem, cells, pluripotency, pluripotent, maintenance, self-renewal, potent, selective, Cyclin-dependent, Kinase, Stem, Cell, Proliferation, 7372, Tocris Bioscience

Citations for CDK8/19i

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