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Description: Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness
Chemical Name: 3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for FzM1.8

FzM1.8 is a frizzled 4 allosteric agonist (pEC50 = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.

Compound Libraries for FzM1.8

FzM1.8 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for FzM1.8

M. Wt 322.32
Formula C18H14N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2204290-85-5
PubChem ID 137553171
Smiles OC(=O)C1=CC(O)=CC(NC(=O)NC2=CC3=C(C=CC=C3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FzM1.8

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.23 100

Preparing Stock Solutions for FzM1.8

The following data is based on the product molecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.03 mL
5 mM 0.62 mL 3.1 mL 6.21 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for FzM1.8

References are publications that support the biological activity of the product.

Riccio et al (2018) A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry 57 839 PMID: 29293331

If you know of a relevant reference for FzM1.8, please let us know.

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View all β-catenin Modulators

Keywords: FzM1.8, FzM1.8 supplier, WNT, receptor, frizzled, 4, allosteric, agonists, agonism, preserves, stemness, β-catenin, FzM18, Beta-catenin, Stem, Cell, Proliferation, 6961, Tocris Bioscience

Citations for FzM1.8

Citations are publications that use Tocris products.

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Pathways for FzM1.8

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.