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Biological Activity for FzM1.8
FzM1.8 is a frizzled 4 allosteric agonist (pEC50 = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.
Compound Libraries for FzM1.8
Technical Data for FzM1.8
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FzM1.8
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FzM1.8
The following data is based on the product molecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.1 mL||15.51 mL||31.03 mL|
|5 mM||0.62 mL||3.1 mL||6.21 mL|
|10 mM||0.31 mL||1.55 mL||3.1 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for FzM1.8
References are publications that support the biological activity of the product.
Riccio et al (2018) A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry 57 839 PMID: 29293331
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Keywords: FzM1.8, FzM1.8 supplier, WNT, receptor, frizzled, 4, allosteric, agonists, agonism, preserves, stemness, β-catenin, FzM18, Beta-catenin, Stem, Cell, Proliferation, 6961, Tocris Bioscience
Citations for FzM1.8
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Literature in this Area
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