INDY

Pricing Availability Delivery Time Qty
Cat.No. 4997 - INDY | C12H13NO2S | CAS No. 1169755-45-6
Description: DYRK1A/B inhibitor
Chemical Name: (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

Technical Data

M. Wt 235.3
Formula C12H13NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1169755-45-6
PubChem ID 69538603
InChI Key GCSZJMUFYOAHFY-UHFFFAOYSA-N
Smiles O=C(C)/C=C1SC2=CC=C(O)C=C2N\1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 235.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.25 mL 21.25 mL 42.5 mL
5 mM 0.85 mL 4.25 mL 8.5 mL
10 mM 0.42 mL 2.12 mL 4.25 mL
50 mM 0.08 mL 0.42 mL 0.85 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Pozo et al (2013) Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest. 123 2475 PMID: 23635774

Ogawa et al (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 1 86 PMID: 20981014


If you know of a relevant reference for INDY, please let us know.

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Keywords: INDY, supplier, INDY, downs, syndrome-related, kinase, Dyrk1A/B, inhibitors, inhibits, tau, phosphorylation, hyperphosphorylation, calcineurin, NFAT, signalling, self-renewal, neural, stem, cells, NSCs, DYRK, Tocris Bioscience

2 Citations for INDY

Citations are publications that use Tocris products. Selected citations for INDY include:

Seu et al (2015) Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection. J Virol 89 6656 PMID: 25878110

Wang et al (2015) A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med 21 383 PMID: 25751815


Do you know of a great paper that uses INDY from Tocris? If so please let us know.

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