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Heparan sulfate antagonist. Inhibits heparan sulfate-mediated cell attachment in vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 445.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.23 mL||56.14 mL||112.27 mL|
|1 mM||2.25 mL||11.23 mL||22.45 mL|
|2 mM||1.12 mL||5.61 mL||11.23 mL|
|10 mM||0.22 mL||1.12 mL||2.25 mL|
References are publications that support the biological activity of the product.
Schuksz et al (2008) Surfen, a small molecule antagonist of heparan sulfate. Proc.Natl.Acad.Sci.USA 105 13074 PMID: 18725627
Huang et al (2018) Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells. 36 45 PMID: 28984039
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Keywords: Surfen, Surfen supplier, human, embryonic, stem, cells, pluripotency, hECS, HS, heparin, sulfate, sulphate, antagonists, antagonism, Cell, Adhesion, Molecules, Stem, Proliferation, 6634, Tocris Bioscience
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