Surfen

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Cat.No. 6634 - Surfen | C21H20N6O.2HCl | CAS No. 5424-37-3
Description: Heparin sulfate antagonist
Chemical Name: N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Heparin sulfate antagonist. Inhibits heparin sulfate-mediated cell attachment in vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.

Technical Data

M. Wt 445.35
Formula C21H20N6O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 5424-37-3
PubChem ID 79472
InChI Key GKQYGRWQCWWSHN-UHFFFAOYSA-N
Smiles CC1=NC2=CC=C(C=C2C(N)=C1)NC(NC3=CC=C4N=C(C=C(C4=C3)N)C)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.91 20
DMSO 8.91 20

Preparing Stock Solutions

The following data is based on the product molecular weight 445.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.23 mL 56.14 mL 112.27 mL
1 mM 2.25 mL 11.23 mL 22.45 mL
2 mM 1.12 mL 5.61 mL 11.23 mL
10 mM 0.22 mL 1.12 mL 2.25 mL

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References

References are publications that support the biological activity of the product.

Schuksz et al (2008) Surfen, a small molecule antagonist of heparan sulfate. Proc.Natl.Acad.Sci.USA 105 13074 PMID: 18725627

Huang et al (2018) Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells. 36 45 PMID: 28984039


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