Stem Cells Scientific Review

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Stem Cells Scientific Review

Using Small Molecules to Control Stem Cell Growth and Differentiation

Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, Durham University

Review excerpt: "Signaling pathways that control cell proliferation and differentiation are important targets for small molecules in the culture of stem cells. Targeting pathways such as the canonical Wnt, transforming growth factor-β (TGF-β) and retinoic acid signaling pathways can be useful to enhance and maintain the proliferation of stem cells, or to guide stem cell fate toward specific lineages in controlled differentiation."