Stem Cells Scientific Review

Request or download your copy today

Stem Cells Scientific Review

Using Small Molecules to Control Stem Cell Growth and Differentiation

Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, Durham University

Review excerpt: "Signaling pathways that control cell proliferation and differentiation are important targets for small molecules in the culture of stem cells. Targeting pathways such as the canonical Wnt, transforming growth factor-β (TGF-β) and retinoic acid signaling pathways can be useful to enhance and maintain the proliferation of stem cells, or to guide stem cell fate toward specific lineages in controlled differentiation."